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a(MESH:Lysosomes)

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Entity

Name
Lysosomes
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 5

The Biology of Proteostasis in Aging and Disease v1.0.0

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading v1.0.0

Clearance systems in the brain-implications for Alzheimer disease. v1.0.1

Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology v1.0.0

In-Edges 4

path(MESH:"Alzheimer Disease") positiveCorrelation a(MESH:Lysosomes) View Subject | View Object

This demonstrates that in the absence of mutant PS1, AD-associated impairment in autophagy occurs and thus is due to other factors. Treatment of ex vivo hippocampal slice cultures with lysosomal disruptors causes the formation of enlarged, dystrophic neurites filled with AVs and lysosomes, similar to what is seen in mouse AD models and human AD tissue (85, 86) PubMed:24027553

Appears in Networks:
Annotations
Text Location
Review

p(HGNC:TFEB) decreases act(a(MESH:Lysosomes)) View Subject | View Object

TFEB activation has been linked to lysosomal stress and the ac- cumulation of aberrant protein aggregates, indicated by TFEB’s nuclear localization in lysosomal storage disorders PubMed:30108137

Appears in Networks:

p(MGI:Tfeb) regulates act(a(MESH:Lysosomes)) View Subject | View Object

In sum, these results demonstrate that TFEB regulates the lysosomal pathway in primary astrocytes. PubMed:30108137

Appears in Networks:
Annotations
Cell Ontology (CL)
astrocyte

complex(a(MESH:Endosomes), a(MESH:Lysosomes)) hasComponent a(MESH:Lysosomes) View Subject | View Object

Appears in Networks:

Out-Edges 4

a(MESH:Lysosomes) increases bp(MESH:Proteolysis) View Subject | View Object

. Proteins can be degraded either individually or en masse by proteasomes (20) or lysosomes (21), respectively. PubMed:25784053

Appears in Networks:

a(MESH:Lysosomes) decreases path(MESH:"Protein Aggregation, Pathological") View Subject | View Object

Alternatively, bulkier substrates, such as large inclusions, can be directed to the lysosome, a membrane-bound organelle containing a host of nonspecific proteases that can degrade a wide range of substrates (21). PubMed:25784053

Appears in Networks:

a(MESH:Lysosomes) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

This demonstrates that in the absence of mutant PS1, AD-associated impairment in autophagy occurs and thus is due to other factors. Treatment of ex vivo hippocampal slice cultures with lysosomal disruptors causes the formation of enlarged, dystrophic neurites filled with AVs and lysosomes, similar to what is seen in mouse AD models and human AD tissue (85, 86) PubMed:24027553

Appears in Networks:
Annotations
Text Location
Review

act(a(MESH:Lysosomes)) decreases p(HGNC:MAPT) View Subject | View Object

starvation or lysosomal dysfunction increases tau release PubMed:29238289

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.