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PubMed: 26337933

Title
Leukocyte expression of heme oxygenase-1 [hmox1] varies inversely with severity of tricuspid regurgitation in acute pulmonary embolism.
Journal
Thrombosis research
Volume
136
Issue
None
Pages
769-74
Date
2015-10-01
Authors
Bonkovsky HL | Courtney M | Kline JA | Steuerwald NM | Watts JA

Evidence c9a7f5b54c
JSON

Humans with severe PE have increased arginase-1 and decreased plasma L-arginine concentrations.[14]

a(CHEBI:"L-arginine") negativeCorrelation path(MESH:"Pulmonary Embolism") View Subject | View Object

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p(HGNC:ARG1) positiveCorrelation path(MESH:"Pulmonary Embolism") View Subject | View Object

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path(MESH:"Pulmonary Embolism") negativeCorrelation a(CHEBI:"L-arginine") View Subject | View Object

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path(MESH:"Pulmonary Embolism") positiveCorrelation p(HGNC:ARG1) View Subject | View Object

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Evidence a483603735
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Release of hemoglobin (and ultimately heme), and arginase-1 into the plasma results in binding of nitric oxide and also reduction in L-arginine, respectively, causing a relative reduction in vasodilatory effect.[14,29]

p(HGNC:HBB) positiveCorrelation complex(a(CHEBI:"nitric oxide"), p(HGNC:HBB)) View Subject | View Object

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Cell Ontology (CL)
leukocyte
MeSH
Plasma
MeSH
Pulmonary Embolism
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p(HGNC:HBB) decreases a(CHEBI:"L-arginine") View Subject | View Object

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Cell Ontology (CL)
leukocyte
MeSH
Plasma
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Pulmonary Embolism
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Discussion

complex(a(CHEBI:"nitric oxide"), p(HGNC:HBB)) positiveCorrelation p(HGNC:HBB) View Subject | View Object

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Cell Ontology (CL)
leukocyte
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Plasma
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Pulmonary Embolism
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Discussion

Evidence 96ef4c09b9
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The median values and associated interquartile ranges for hmox-1 and haptoglobin show that patients with PE+TR+ had lower expression of these genes compared with patients who were PE+TR− or PE−

p(HGNC:HP) negativeCorrelation path(MESH:"Tricuspid Valve Insufficiency") View Subject | View Object

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Pulmonary Embolism
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Results

p(HGNC:HMOX1) negativeCorrelation path(MESH:"Tricuspid Valve Insufficiency") View Subject | View Object

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Pulmonary Embolism
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path(MESH:"Tricuspid Valve Insufficiency") negativeCorrelation p(HGNC:HMOX1) View Subject | View Object

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Pulmonary Embolism
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path(MESH:"Tricuspid Valve Insufficiency") negativeCorrelation p(HGNC:HP) View Subject | View Object

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Pulmonary Embolism
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Evidence 0dc6e92bcf
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Table 3 shows a significant increase in the median value for the plasma biomarker of hemolysis, arginase-1 in patients with PE+TR+ by pairwise comparison using the Kruskal-Wallis test.

p(HGNC:ARG1) positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

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Pulmonary Embolism
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p(HGNC:ARG1) positiveCorrelation path(MESH:"Tricuspid Valve Insufficiency") View Subject | View Object

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MeSH
Pulmonary Embolism
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Results

path(MESH:"Tricuspid Valve Insufficiency") positiveCorrelation p(HGNC:ARG1) View Subject | View Object

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Pulmonary Embolism
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path(MESH:Hemolysis) positiveCorrelation p(HGNC:ARG1) View Subject | View Object

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Pulmonary Embolism
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Evidence 7244d5ced0
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The inverse correlation between hmox-1 expression in circulating leukocytes and the TR jet velocity in patients with acute PE was significant (r2=0.45, p <0.001), but this significance was absent in patients without PE (r2=0.01, P=0.52).

p(HGNC:HMOX1) negativeCorrelation path(MESH:"Tricuspid Valve Insufficiency") View Subject | View Object

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Cell Ontology (CL)
leukocyte
MeSH
Pulmonary Embolism
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Results

path(MESH:"Tricuspid Valve Insufficiency") negativeCorrelation p(HGNC:HMOX1) View Subject | View Object

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Cell Ontology (CL)
leukocyte
MeSH
Pulmonary Embolism
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Evidence 213900ebb9
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We hypothesize acute moderate to severe PE causes turbulent flow across the tricuspid and pulmonic valves and in the pulmonary tree, causing rupture of a small percentage of red cells in or immediately proximal to or within the pulmonary vascular tree.

path(MESH:"Pulmonary Embolism") positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

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Cell Ontology (CL)
leukocyte
MeSH
Pulmonary Embolism
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Discussion

path(MESH:Hemolysis) positiveCorrelation path(MESH:"Pulmonary Embolism") View Subject | View Object

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Cell Ontology (CL)
leukocyte
MeSH
Pulmonary Embolism
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Discussion

Evidence 6933388baa
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The cyclooxygenase-2 gene was not significantly different between groups and had no correlation with the TR jet velocity in patients with PE (R2=0.03).

path(MESH:"Tricuspid Valve Insufficiency") causesNoChange g(HGNC:PTGS2) View Subject | View Object

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Pulmonary Embolism
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Results

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