a(CHEBI:paraquat) increases p(HGNC:CASP1)

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PubMed:28019679

Using the herbizide, N,N0-dimethyl-4,40-bipyridinium dichloride (paraquat) as a mitochondrial toxin, which is known to induce oxidative stress, Chen et al. found increased levels of caspase-1 and IL-1b in brain of wild type and APP/PS1 transgenic mice (2), suggesting that those were due to NLRP3 inflammasome activation

Related Edges 4

• a(CHEBI:paraquat) increases act(complex(GO:"NLRP3 inflammasome complex"))
• a(CHEBI:paraquat) increases p(HGNC:IL1B)
• act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:IL1B)
• act(complex(GO:"NLRP3 inflammasome complex")) increases p(HGNC:CASP1)

Confidence

High

MeSH

Neurons

NeuroMMSigDB

Caspase subgraph

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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