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bp(GO:"neutrophil activation")

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Entity

Name
neutrophil activation
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 2

Activation and regulation of the inflammasomes v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

act(p(HGNC:IL1B)) increases bp(GO:"neutrophil activation") View Subject | View Object

Caspase 1mediated activation of members of the IL-1β cytokine family leads to the recruitment and the activation of other immune cells, such as neutrophils, at the site of infection and/or tissue damage. PubMed:23702978

Appears in Networks:
Annotations
Confidence
High
NeuroMMSigDB
Caspase subgraph
NeuroMMSigDB
Interleukin signaling subgraph

a(MESH:"Extracellular Traps") positiveCorrelation bp(GO:"neutrophil activation") View Subject | View Object

Heme-induced neutrophils activation leads to extracellular traps (NETs) release through a mechanism dependent on ROS generation (Chen et al., 2014). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(CHEBI:heme) increases bp(GO:"neutrophil activation") View Subject | View Object

Heme-induced neutrophils activation leads to extracellular traps (NETs) release through a mechanism dependent on ROS generation (Chen et al., 2014). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

a(CHEBI:heme) increases bp(GO:"neutrophil activation") View Subject | View Object

Heme is one of the factors capable of inducing stimulation and damage of endothelium, promoting the recruitment of neutrophils and sickle-cell erythro- cytes, and subsequently prompting a vaso-occlusive crisis. PubMed:26875449

Appears in Networks:
Annotations
MeSH
Anemia, Sickle Cell
Text Location
Review

a(CHEBI:heme) positiveCorrelation bp(GO:"neutrophil activation") View Subject | View Object

By modeling the equilibrium concentration in the experiments performed with heme-albumin we could show that the free heme is the active neutrophil-stimulating component, which is inactivated by protein association (Figure S2). PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
Text Location
Results

Out-Edges 2

bp(GO:"neutrophil activation") positiveCorrelation a(MESH:"Extracellular Traps") View Subject | View Object

Heme-induced neutrophils activation leads to extracellular traps (NETs) release through a mechanism dependent on ROS generation (Chen et al., 2014). PubMed:24904418

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Text Location
Review

bp(GO:"neutrophil activation") positiveCorrelation a(CHEBI:heme) View Subject | View Object

By modeling the equilibrium concentration in the experiments performed with heme-albumin we could show that the free heme is the active neutrophil-stimulating component, which is inactivated by protein association (Figure S2). PubMed:29610666

Appears in Networks:
Annotations
Cell Ontology (CL)
neutrophil
Text Location
Results

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.