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a(CHEBI:chlorobutanol)

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Entity

Name
chlorobutanol
Namespace
chebi
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/chebi-names.belns

Appears in Networks 1

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse v1.0.0

In-Edges 2

composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) hasComponent a(CHEBI:chlorobutanol) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:chlorobutanol), p(HGNC:ADNP, pmod(MESH:Haploinsufficiency))) hasComponent a(CHEBI:chlorobutanol) View Subject | View Object

Appears in Networks:

Out-Edges 7

a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) View Subject | View Object

Figure 1a shows enhanced brain/body bioavailability in the presence of the newly tested vehicle, chlorobutanol over time. PubMed:30664622

Appears in Networks:

a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:"Cell Body")) View Subject | View Object

Figure 1a shows enhanced brain/body bioavailability in the presence of the newly tested vehicle, chlorobutanol over time. PubMed:30664622

Appears in Networks:

a(CHEBI:chlorobutanol) increases tloc(a(PUBCHEM:9832404), fromLoc(GO:"extracellular region"), toLoc(MESH:Brain)) View Subject | View Object

Fig. 1b displays enhanced brain bioavailability by picture evaluation. Fig. 1c shows quantitative assessment of three independent experiments, revealing the dramatic 4-fold increase in specific brain bioavailability. PubMed:30664622

Appears in Networks:

a(CHEBI:chlorobutanol) causesNoChange a(MESH:"Blood-Brain Barrier") View Subject | View Object

These findings provide clear evidence that the blood brain barrier remained intact in the presence of chlorobutanol PubMed:30664622

Appears in Networks:

a(CHEBI:chlorobutanol) increases bp(GO:"social behavior") View Subject | View Object

We have also extended the experiments to female mice, and interestingly, in the social recognition test CB- or NAP-treated females displayed significant preference to mice rather than objects (Supplemental Fig. S2C), unlike previous findings with the “DD” formulation. PubMed:30664622

Appears in Networks:
Annotations
Gender
Female

a(CHEBI:chlorobutanol) causesNoChange path(MESH:Smell) View Subject | View Object

As social behavior depends on olfaction, this was also measured showing intact odor discrimination ability in CB-treated males (Fig. 2e) and a sex difference, with no preference for a specific olfactory cue in CB-treated females (Supplemental Fig. S2E), thus corroborating previous findings observed for DD-treated mice PubMed:30664622

Appears in Networks:
Annotations
Gender
Male

a(CHEBI:chlorobutanol) decreases path(MESH:Smell) View Subject | View Object

As social behavior depends on olfaction, this was also measured showing intact odor discrimination ability in CB-treated males (Fig. 2e) and a sex difference, with no preference for a specific olfactory cue in CB-treated females (Supplemental Fig. S2E), thus corroborating previous findings observed for DD-treated mice PubMed:30664622

Appears in Networks:
Annotations
Gender
Female

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.