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composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404))

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Components

Appears in Networks 1

The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse v1.0.0

In-Edges 0

Out-Edges 5

composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) hasComponent a(CHEBI:chlorobutanol) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) hasComponent a(PUBCHEM:9832404) View Subject | View Object

Appears in Networks:

composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:memory) View Subject | View Object

Adnp+/− mice compared with Adnp+/+ mice spent significantly shorter time periods in exploring the new objects, indicative of impaired memory, with intranasal NAP-CB treatment completely ameliorating this impairment (Fig. 2a, b). PubMed:30664622

Appears in Networks:

composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases bp(GO:"social behavior") View Subject | View Object

While no effect was observed in the Adnp+/− male mouse social recognition, with preference to mice rather than objects (Fig. 2c), Adnp haploinsufficiency showed significantly inhibited social memory, which was completely ameliorated by NAP-CB treatment (Fig. 2d). PubMed:30664622

Appears in Networks:

composite(a(CHEBI:chlorobutanol), a(PUBCHEM:9832404)) increases a(MESH:"Nerve Fibers, Myelinated") View Subject | View Object

Furthermore, FA which is used to characterize the organization of white matter fibers, was shown to be significantly increased in Adnp+/− mice, thus implying of structural impairment. Importantly, this DTI observed structural impairment was ameliorated by NA-PCB treatment (Fig. 3b). PubMed:30664622

Appears in Networks:
Annotations
MeSH
White Matter

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.