bp(GO:"social behavior")

Entity

Name

social behavior

Namespace

go

Namespace Version

20190224

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/go-names.belns

We evaluated the 31 transcripts regulated at both tested ages (see above) and found that the most enriched modified functions were related to nervous system development and activity including synapse assembly, positive regulation of synaptic transmission, glutamatergic, regulation of synapse organization, regulation of cell communication, α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) glutamate receptor clustering, learning or memory, social behavior, regulation of ion transport, vocalization behavior, and nervous system development (Figure 3, Supplemental Tables 11 and 12) PubMed:30106381

As with object recognition memory, the deficient social memory of Adnp+/– mice (males and females) was normalized by NAP treatment (Figure 7F). PubMed:30106381

We evaluated the 31 transcripts regulated at both tested ages (see above) and found that the most enriched modified functions were related to nervous system development and activity including synapse assembly, positive regulation of synaptic transmission, glutamatergic, regulation of synapse organization, regulation of cell communication, α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) glutamate receptor clustering, learning or memory, social behavior, regulation of ion transport, vocalization behavior, and nervous system development (Figure 3, Supplemental Tables 11 and 12) PubMed:30106381

As with object recognition memory, the deficient social memory of Adnp+/– mice (males and females) was normalized by NAP treatment (Figure 7F). PubMed:30106381

We have also extended the experiments to female mice, and interestingly, in the social recognition test CB- or NAP-treated females displayed significant preference to mice rather than objects (Supplemental Fig. S2C), unlike previous findings with the “DD” formulation. PubMed:30664622

We have also extended the experiments to female mice, and interestingly, in the social recognition test CB- or NAP-treated females displayed significant preference to mice rather than objects (Supplemental Fig. S2C), unlike previous findings with the “DD” formulation. PubMed:30664622

Furthermore, in both sexes, Adnp haploinsufficiency showed significantly inhibited social memory, which was completely ameliorated by NAP treatment (Fig. 2d, males and Supplemental Fig. S2D, females). PubMed:30664622

While no effect was observed in the Adnp+/− male mouse social recognition, with preference to mice rather than objects (Fig. 2c), Adnp haploinsufficiency showed significantly inhibited social memory, which was completely ameliorated by NAP-CB treatment (Fig. 2d). PubMed:30664622

While no effect was observed in the Adnp+/− male mouse social recognition, with preference to mice rather than objects (Fig. 2c), Adnp haploinsufficiency showed significantly inhibited social memory, which was completely ameliorated by NAP-CB treatment (Fig. 2d). PubMed:30664622

Furthermore, in both sexes, Adnp haploinsufficiency showed significantly inhibited social memory, which was completely ameliorated by NAP treatment (Fig. 2d, males and Supplemental Fig. S2D, females). PubMed:30664622

While no effect was observed in the Adnp+/− male mouse social recognition, with preference to mice rather than objects (Fig. 2c), Adnp haploinsufficiency showed significantly inhibited social memory, which was completely ameliorated by NAP-CB treatment (Fig. 2d). PubMed:30664622

We have also extended the experiments to female mice, and interestingly, in the social recognition test CB- or NAP-treated females displayed significant preference to mice rather than objects (Supplemental Fig. S2C), unlike previous findings with the “DD” formulation. PubMed:30664622

As social behavior depends on olfaction, this was also measured showing intact odor discrimination ability in CB-treated males (Fig. 2e) and a sex difference, with no preference for a specific olfactory cue in CB-treated females (Supplemental Fig. S2E), thus corroborating previous findings observed for DD-treated mice PubMed:30664622

We evaluated the 31 transcripts regulated at both tested ages (see above) and found that the most enriched modified functions were related to nervous system development and activity including synapse assembly, positive regulation of synaptic transmission, glutamatergic, regulation of synapse organization, regulation of cell communication, α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) glutamate receptor clustering, learning or memory, social behavior, regulation of ion transport, vocalization behavior, and nervous system development (Figure 3, Supplemental Tables 11 and 12) PubMed:30106381

We evaluated the 31 transcripts regulated at both tested ages (see above) and found that the most enriched modified functions were related to nervous system development and activity including synapse assembly, positive regulation of synaptic transmission, glutamatergic, regulation of synapse organization, regulation of cell communication, α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) glutamate receptor clustering, learning or memory, social behavior, regulation of ion transport, vocalization behavior, and nervous system development (Figure 3, Supplemental Tables 11 and 12) PubMed:30106381