The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.
|Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome v1.0.0||35%|
|Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice v1.0.0||33%|
|Tau Modifications v1.9.5||15%|
|Tau in physiology and pathology v1.0.0||15%|
|mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0||15%|
|Nuclear Factor Kappa-light-chain-enhancer of Activated B Cells (NF-κB) - a Friend, a Foe, or a Bystander - in the Neurodegenerative Cascade and Pathogenesis of Alzheimer's Disease v1.0.0||12%|
|Activation of M1 and M4 muscarinic receptors as potential treatments for Alzheimer's disease and schizophrenia. v1.0.0||8%|
|Role of the nicotinic acetylcholine receptor in Alzheimer's disease pathology and treatment v1.0.1||8%|
|Nuclear receptors as therapeutic targets for Alzheimer's disease. v1.0.0||8%|
|Tau oligomers-Cytotoxicity, propagation, and mitochondrial damage v1.0.0||8%|
Further results showed no significant brain penetration of Evans blue ( < 0.1 ng/ml, which was the limit of detection), and no difference between chlorobutanol and saline.
Representative pictures show penetration of the Evans blue dye in the periphery (Fig. 1d), but not in the brain (Fig. 1e), with brain concentration values < 0.03 ng/ml (Supplemental Fig. S1)
BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.
If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.