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p(HGNC:TFEB)

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Entity

Name
TFEB
Namespace
hgnc
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/hgnc-symbols.belns

Appears in Networks 5

Alpha-synuclein oligomers: a new hope v1.0.0

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading v1.0.0

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

In-Edges 9

p(HGNC:TFEB, pmod(Ph)) decreases act(p(HGNC:TFEB)) View Subject | View Object

TFEB at normal state is phosphorylated by mTOR complex 1, which inhibits its activity PubMed:29758300

Appears in Networks:

p(FPLX:mTORC1) decreases tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) View Subject | View Object

mTORC1 also restrains autophagy by preventing nuclear translo- cation of TFEB 20 . PubMed:30116051

Appears in Networks:

act(p(FPLX:mTORC1)) increases act(p(HGNC:TFEB)) View Subject | View Object

Moreover, the flavonol fisetin stimulated auto- phagic degradation of phosphorylated tau in cortical neu- rons via mTORC1-dependent activation of TFEB and the cytoprotective transcription factor nuclear factor eryth- roid 2-related factor 2 (NFE2L2) 149 . Fisetin also reduced Aβ accumulation in an APP/PS1 mouse model of AD 150 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Machado-Joseph Disease

path(MESH:"Frontotemporal Dementia") increases p(HGNC:TFEB) View Subject | View Object

On the protein level, TFEB lysosomal target genes LAMP1 and Cathep- sin D (CTSD) are also increased in the FTD frontal cortex relative to normal subjects, and TFEB protein levels trended increased with statistical significance in the CBD group PubMed:30108137

Appears in Networks:

bp(GO:"cellular response to stress") increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) View Subject | View Object

Under starvation or stress, TFEB translocates to the nucleus and binds the CRE element to promote expression of macroautophagy and lysosomal genes [88]. PubMed:29758300

Appears in Networks:

complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) hasComponent p(HGNC:TFEB) View Subject | View Object

Appears in Networks:

composite(p(HGNC:PTEN), p(HGNC:TFEB)) hasComponent p(HGNC:TFEB) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") association p(HGNC:TFEB) View Subject | View Object

Another modulator of A-LS implicated in AD pathology is transcription factor EB (TFEB), a master regulator of lysosome biogenesis PubMed:29758300

Appears in Networks:

path(MESH:Starvation) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) View Subject | View Object

Under starvation or stress, TFEB translocates to the nucleus and binds the CRE element to promote expression of macroautophagy and lysosomal genes [88]. PubMed:29758300

Appears in Networks:

Out-Edges 21

p(HGNC:TFEB) regulates bp(GO:autophagy) View Subject | View Object

Another modulator of A-LS implicated in AD pathology is transcription factor EB (TFEB), a master regulator of lysosome biogenesis PubMed:29758300

Appears in Networks:

p(HGNC:TFEB) decreases a(HBP:HBP00093) View Subject | View Object

Accordingly, overexpression of transcription factor EB (TFEB) was shown to correct lysosomal defects induced by the viral overexpression of a-syn and to downregulate the accumulation of oligomers in vivo [32]. PubMed:28803412

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

p(HGNC:TFEB) increases bp(GO:macroautophagy) View Subject | View Object

Unc-51-like kinase 1 (ULK1) is primarily an autophagy-initiating protein 3,10,19 , as is the mTORC1- suppressed transcrip- tion factor EB (TFEB), which orchestrates the synthesis of lysosomal and other proteins critical for maintaining ALN flux 20–23 . PubMed:30116051

Appears in Networks:

tloc(p(HGNC:TFEB), fromLoc(MESH:Cytoplasm), toLoc(MESH:"Cell Nucleus")) increases bp(GO:macroautophagy) View Subject | View Object

mTORC1 also restrains autophagy by preventing nuclear translo- cation of TFEB 20 . PubMed:30116051

Appears in Networks:

p(HGNC:TFEB) decreases a(HBP:HBP00018) View Subject | View Object

Indeed, TFEB over- expression reduced amyloid plaques in a APP/PS1 mouse model 148 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons
MeSH
Machado-Joseph Disease

p(HGNC:TFEB) decreases act(a(MESH:Lysosomes)) View Subject | View Object

TFEB activation has been linked to lysosomal stress and the ac- cumulation of aberrant protein aggregates, indicated by TFEB’s nuclear localization in lysosomal storage disorders PubMed:30108137

Appears in Networks:

p(HGNC:TFEB) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

Transcriptional factor EB downregulates Aβ levels by affecting autophagy-lysosome (Zhang and Zhao 2015) PubMed:29626319

Appears in Networks:

p(HGNC:TFEB) increases deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

Xiao et al. have also obtained the consistent conclusion that transcriptional factor EB, a master regulator of lysosome biogenesis, improves lysosomal function in astrocytes, which may promote Aβ clearance and attenuate plaque pathogenesis (Xiao et al. 2014) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Astrocytes

p(HGNC:TFEB) regulates deg(a(CHEBI:"amyloid-beta")) View Subject | View Object

For example, like Aβ, clearance of pTau/NFT also can be regulated by TFEB, which increases the activity of autophagy and lysosome (Polito et al. 2014) PubMed:29626319

Appears in Networks:

p(HGNC:TFEB) increases act(a(GO:lysosome)) View Subject | View Object

Xiao et al. have also obtained the consistent conclusion that transcriptional factor EB, a master regulator of lysosome biogenesis, improves lysosomal function in astrocytes, which may promote Aβ clearance and attenuate plaque pathogenesis (Xiao et al. 2014) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Astrocytes

p(HGNC:TFEB) increases act(a(GO:lysosome)) View Subject | View Object

For example, like Aβ, clearance of pTau/NFT also can be regulated by TFEB, which increases the activity of autophagy and lysosome (Polito et al. 2014) PubMed:29626319

Appears in Networks:

p(HGNC:TFEB) decreases path(MESH:"Plaque, Amyloid") View Subject | View Object

Xiao et al. have also obtained the consistent conclusion that transcriptional factor EB, a master regulator of lysosome biogenesis, improves lysosomal function in astrocytes, which may promote Aβ clearance and attenuate plaque pathogenesis (Xiao et al. 2014) PubMed:29626319

Appears in Networks:
Annotations
MeSH
Astrocytes

p(HGNC:TFEB) regulates deg(a(MESH:"Neurofibrillary Tangles")) View Subject | View Object

For example, like Aβ, clearance of pTau/NFT also can be regulated by TFEB, which increases the activity of autophagy and lysosome (Polito et al. 2014) PubMed:29626319

Appears in Networks:

p(HGNC:TFEB) regulates deg(p(HGNC:MAPT, pmod(Ph))) View Subject | View Object

For example, like Aβ, clearance of pTau/NFT also can be regulated by TFEB, which increases the activity of autophagy and lysosome (Polito et al. 2014) PubMed:29626319

Appears in Networks:

p(HGNC:TFEB) increases bp(GO:autophagy) View Subject | View Object

For example, like Aβ, clearance of pTau/NFT also can be regulated by TFEB, which increases the activity of autophagy and lysosome (Polito et al. 2014) PubMed:29626319

Appears in Networks:

p(HGNC:TFEB) hasVariant p(HGNC:TFEB, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(HGNC:TFEB) regulates a(GO:lysosome) View Subject | View Object

Another modulator of A-LS implicated in AD pathology is transcription factor EB (TFEB), a master regulator of lysosome biogenesis PubMed:29758300

Appears in Networks:

p(HGNC:TFEB) increases bp(GO:autophagy) View Subject | View Object

TFEB has been shown to effectively clear phosphorylated tau proteins through A-LS, resulting in ameliorated neuronal loss and neuroinflammation, as well as improved cognitive performance [89]. PubMed:29758300

Appears in Networks:

p(HGNC:TFEB) association path(MESH:"Alzheimer Disease") View Subject | View Object

Another modulator of A-LS implicated in AD pathology is transcription factor EB (TFEB), a master regulator of lysosome biogenesis PubMed:29758300

Appears in Networks:

p(HGNC:TFEB) increases deg(p(HGNC:MAPT, pmod(Ph))) View Subject | View Object

TFEB has been shown to effectively clear phosphorylated tau proteins through A-LS, resulting in ameliorated neuronal loss and neuroinflammation, as well as improved cognitive performance [89]. PubMed:29758300

Appears in Networks:

p(HGNC:TFEB) increases act(p(HGNC:PTEN)) View Subject | View Object

Activation of PTEN, another inducer of macroautophagy, by TFEB is indispensable for this TFEB-mediated increase in macroautophagy [89] PubMed:29758300

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.