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path(MESH:Starvation)

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Entity

Name
Starvation
Namespace
mesh
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/mesh-names.belns

Appears in Networks 3

Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology v1.0.0

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0

In-Edges 0

Out-Edges 5

path(MESH:Starvation) increases p(HGNC:MAPT) View Subject | View Object

starvation or lysosomal dysfunction increases tau release PubMed:29238289

Appears in Networks:

path(MESH:Starvation) increases rxn(reactants(a(CHEBI:lipid)), products(a(CHEBI:"fatty acid"))) View Subject | View Object

Cytosolic lipids are stored as triglycerides in lipid droplets and are hydrolyzed into fatty acid for energy under nutrient starvation PubMed:29758300

Appears in Networks:

path(MESH:Starvation) increases tloc(p(HGNC:TFEB), fromLoc(GO:cytosol), toLoc(GO:nucleus)) View Subject | View Object

Under starvation or stress, TFEB translocates to the nucleus and binds the CRE element to promote expression of macroautophagy and lysosomal genes [88]. PubMed:29758300

Appears in Networks:

path(MESH:Starvation) increases complex(p(HGNC:TFEB), p(INTERPRO:"cAMP response element binding (CREB) protein")) View Subject | View Object

Under starvation or stress, TFEB translocates to the nucleus and binds the CRE element to promote expression of macroautophagy and lysosomal genes [88]. PubMed:29758300

Appears in Networks:

path(MESH:Starvation) increases tloc(p(HGNC:WDFY3), fromLoc(GO:nucleus), toLoc(GO:cytoplasm)) View Subject | View Object

In cells that are exposed to stressors such as starvation or UPS inhibition, Alfy relocalizes from the nuclear envelope to filamentous cytoplasmic structures that are near autophagic membranes and ubiquitinated protein inclusions, as well as within autophagosomes [77]. PubMed:18930136

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.