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p(HGNC:HSD17B10)

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Entity

Name
HSD17B10
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 1

Amyloid-Binding Alcohol Dehydrogenase (ABAD) Inhibitors for the Treatment of Alzheimer’s Disease v1.0.0

In-Edges 8

a(HBP:AG18051) decreases act(p(HGNC:HSD17B10)) View Subject | View Object

A potent ABAD inhibitor, AG18051 (1), containing a pyrazolo[3,4-d] pyrimidine-4(1H)-thione backbone (IC 50 = 92 nM) has been reported. PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

a(CHEBI:"methylene blue") decreases p(HGNC:HSD17B10) View Subject | View Object

In mechanistic studies, it was proposed that methylene blue inhibits the Aβ-ABAD interaction and decreases mitochondrial dysfunction by decreasing the expression of ABAD levels, in addition to decreasing Aβ levels. PubMed:30444369

Appears in Networks:

a(HBP:"RM-532-46") decreases act(p(HGNC:HSD17B10)) View Subject | View Object

Interestingly, during the search for inhibitors of 17β-HSD isoforms for the treatment of estrogen- related diseases, 127 Ayan et.al identified the steroidal compound RM-532-46 (8) as a reversible ABAD inhibitor (IC 50 = 0.55 M). PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

complex(a(CHEBI:"NAD(+)"), p(HGNC:HSD17B10)) hasComponent p(HGNC:HSD17B10) View Subject | View Object

Appears in Networks:

complex(p(HGNC:APP), p(HGNC:HSD17B10)) hasComponent p(HGNC:HSD17B10) View Subject | View Object

Appears in Networks:

complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(HGNC:HSD17B10)) View Subject | View Object

However, it is well established that Aβ binding to ABAD induces a conformational change in the enzyme that prevents the binding of NAD + , preventing the enzyme performing its role in the oxidation of substrates, leading to changes in mitochondrial membrane permeability, which in turn has deleterious effects on mitochondrial enzymes. PubMed:30444369

Appears in Networks:
Annotations
MeSH
Neurons

p(FPLX:GABR) association act(p(HGNC:HSD17B10)) View Subject | View Object

Moreover, function of ABAD has also been associated with GABA A receptors, as it catalyzes the oxidation of the neurosteroids allopregnanolone and allotetrahydrodeoxycorticosterone, both of which are positive modulators of GABA A receptors in the brain. PubMed:30444369

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:HSD17B10) View Subject | View Object

Binding of Aβ to ABAD has been implicated in the development of AD, recent studies detected elevated ABAD levels in the regions of the hippocampus and cerebral cortex which are generally affected by AD pathology PubMed:30444369

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus

Out-Edges 6

p(HGNC:HSD17B10) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Binding of Aβ to ABAD has been implicated in the development of AD, recent studies detected elevated ABAD levels in the regions of the hippocampus and cerebral cortex which are generally affected by AD pathology PubMed:30444369

Appears in Networks:
Annotations
MeSH
Cerebral Cortex
MeSH
Hippocampus

act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:440326)), products(a(PUBCHEM:193425))) View Subject | View Object

The enzyme is also required for the catabolism of isoleucine, in which it catalyzes the conversion of 2-methyl-3-hydroxybutyryl-coA (MHB) to 2-methyl-acetoacetyl-coA. 72 PubMed:30444369

Appears in Networks:

act(p(HGNC:HSD17B10)) increases rxn(reactants(a(CHEBI:"NAD(+)"), a(PUBCHEM:9543037)), products(a(CHEBI:"3-oxo-fatty acyl-CoA(4-)"), a(CHEBI:NADH), a(PUBCHEM:1038))) View Subject | View Object

The enzyme catalyzes the third step of mitochondrial oxidation, converting L -3-hydroxyacyl-CoA in the presence of NAD + to 3-ketoacyl-CoA, NADH, and H + . PubMed:30444369

Appears in Networks:

act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:15818)), products(a(PUBCHEM:10635))) View Subject | View Object

The oxidation of 3-adiol to 5-dihydrotestosterone in androgen metabolism is catalyzed by ABAD and it converts 17β-estradiol to estrone in estrogen metabolism. PubMed:30444369

Appears in Networks:

act(p(HGNC:HSD17B10)) increases rxn(reactants(a(PUBCHEM:5757)), products(a(PUBCHEM:5870))) View Subject | View Object

The oxidation of 3-adiol to 5-dihydrotestosterone in androgen metabolism is catalyzed by ABAD and it converts 17β-estradiol to estrone in estrogen metabolism. PubMed:30444369

Appears in Networks:

act(p(HGNC:HSD17B10)) association p(FPLX:GABR) View Subject | View Object

Moreover, function of ABAD has also been associated with GABA A receptors, as it catalyzes the oxidation of the neurosteroids allopregnanolone and allotetrahydrodeoxycorticosterone, both of which are positive modulators of GABA A receptors in the brain. PubMed:30444369

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.