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a(CHEBI:"methylene blue")

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Entity

Name
methylene blue
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 11

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

Tau clearance mechanisms and their possible role in the pathogenesis of Alzheimer disease v1.0.0

Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. v1.0.0

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies v1.0.0

Clearance of Amyloid Beta and Tau in Alzheimer’s Disease:from Mechanisms to Therapy v1.0.1

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Amyloid-Binding Alcohol Dehydrogenase (ABAD) Inhibitors for the Treatment of Alzheimer’s Disease v1.0.0

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity v1.0.0

Caenorhabditis elegans models of tauopathy v1.0.0

In-Edges 1

bp(GO:locomotion) positiveCorrelation a(CHEBI:"methylene blue") View Subject | View Object

For example, Fatouros et al. (68) tested several tau-aggregation inhibitor compounds such as methylene blue, a rhodanine derivative (bb14), and a phenylthiazolyl hydrazide derivative (BSc3094), which reduce the insoluble tau and partially suppress the Unc phenotype. PubMed:29191965

Appears in Networks:

Out-Edges 35

a(CHEBI:"methylene blue") decreases a(HBP:HBP00009) View Subject | View Object

For example, methylene blue coun- ters tau oligomerization and promotes autophagy 101,102 (Supplementary Table 4). PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

a(CHEBI:"methylene blue") increases bp(GO:autophagy) View Subject | View Object

For example, methylene blue coun- ters tau oligomerization and promotes autophagy 101,102 (Supplementary Table 4). PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

a(CHEBI:"methylene blue") increases bp(GO:autophagy) View Subject | View Object

Other compounds that act through AMPK acti- vation include the antiaggregant methylene blue (Supplementary Box 1), which elevated levels of beclin  1, p62 and LC3, induced autophagy and suppressed tau in organotypic neuronal cultures and a mouse model of FTD 101,102 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

a(CHEBI:"methylene blue") increases act(p(FPLX:AMPK)) View Subject | View Object

Other compounds that act through AMPK acti- vation include the antiaggregant methylene blue (Supplementary Box 1), which elevated levels of beclin  1, p62 and LC3, induced autophagy and suppressed tau in organotypic neuronal cultures and a mouse model of FTD 101,102 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

a(CHEBI:"methylene blue") increases p(HGNC:BECN1) View Subject | View Object

Other compounds that act through AMPK acti- vation include the antiaggregant methylene blue (Supplementary Box 1), which elevated levels of beclin  1, p62 and LC3, induced autophagy and suppressed tau in organotypic neuronal cultures and a mouse model of FTD 101,102 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3A) View Subject | View Object

Other compounds that act through AMPK acti- vation include the antiaggregant methylene blue (Supplementary Box 1), which elevated levels of beclin  1, p62 and LC3, induced autophagy and suppressed tau in organotypic neuronal cultures and a mouse model of FTD 101,102 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

a(CHEBI:"methylene blue") increases p(HGNC:DCTN4) View Subject | View Object

Other compounds that act through AMPK acti- vation include the antiaggregant methylene blue (Supplementary Box 1), which elevated levels of beclin  1, p62 and LC3, induced autophagy and suppressed tau in organotypic neuronal cultures and a mouse model of FTD 101,102 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

a(CHEBI:"methylene blue") decreases act(p(HGNC:MAPT)) View Subject | View Object

Other compounds that act through AMPK acti- vation include the antiaggregant methylene blue (Supplementary Box 1), which elevated levels of beclin  1, p62 and LC3, induced autophagy and suppressed tau in organotypic neuronal cultures and a mouse model of FTD 101,102 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Dopaminergic Neurons

a(CHEBI:"methylene blue") increases bp(MESH:Autophagy) View Subject | View Object

Additionally, in a hippocampal slice preparation, induction of autophagy by treatment with methylene blue led to a decrease in phosphorylated tau and insoluble tau without an effect on total tau (95). PubMed:24027553

Appears in Networks:
Annotations
MeSH
Hippocampus
Text Location
Review

a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") View Subject | View Object

Methylene blue, which has been known to directly inhibit tau aggregation, is also capable to induce autophagy and reduce total and phospho-tau levels with improved cognitive performance in tau transgenic mice by oral administration (Congdon et al., 2012). PubMed:23528736

Appears in Networks:

a(CHEBI:"methylene blue") increases bp(GO:autophagy) View Subject | View Object

Methylene blue, which has been known to directly inhibit tau aggregation, is also capable to induce autophagy and reduce total and phospho-tau levels with improved cognitive performance in tau transgenic mice by oral administration (Congdon et al., 2012). PubMed:23528736

Appears in Networks:

a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) View Subject | View Object

Methylene blue, which has been known to directly inhibit tau aggregation, is also capable to induce autophagy and reduce total and phospho-tau levels with improved cognitive performance in tau transgenic mice by oral administration (Congdon et al., 2012). PubMed:23528736

Appears in Networks:

a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ph)) View Subject | View Object

Methylene blue, which has been known to directly inhibit tau aggregation, is also capable to induce autophagy and reduce total and phospho-tau levels with improved cognitive performance in tau transgenic mice by oral administration (Congdon et al., 2012). PubMed:23528736

Appears in Networks:

a(CHEBI:"methylene blue") decreases act(p(INTERPRO:"Heat shock protein 70 family")) View Subject | View Object

As might be expected given the diverse mechanisms of these compounds, known Hsp70 inhibitors represent a variety of chemical classes, including dihydropyrimidines, adenosine analogs, polyamines and others (Figure 1) [52,63]. Moreover, many of these inhibitors, including methylene blue and MKT-077, have poorly understood mechanisms PubMed:21882945

Appears in Networks:

a(CHEBI:"methylene blue") decreases p(HBP:"Tau aggregates") View Subject | View Object

MB is a phenothiazine that crosses the blood brain barrier and acts as a redox cycler. Moreover, besides its beneficial properties as being able to improve energy metabolism and to act as an antioxidant, it is also able to reduce tau protein aggregation PubMed:26751493

Appears in Networks:

a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP1)) View Subject | View Object

MB is a phenothiazine that crosses the blood brain barrier and acts as a redox cycler. Moreover, besides its beneficial properties as being able to improve energy metabolism and to act as an antioxidant, it is also able to reduce tau protein aggregation PubMed:26751493

Appears in Networks:

a(CHEBI:"methylene blue") decreases act(p(HGNC:CASP3)) View Subject | View Object

MB is a phenothiazine that crosses the blood brain barrier and acts as a redox cycler. Moreover, besides its beneficial properties as being able to improve energy metabolism and to act as an antioxidant, it is also able to reduce tau protein aggregation PubMed:26751493

Appears in Networks:

a(CHEBI:"methylene blue") increases bp(GO:autophagy) View Subject | View Object

Recent acknowledged drugs can improve autophagy by acting on the process of autophagy-lysosome formation and then increasing tau clearance, such as methylene blue, lithium, and trehalose (Congdon et al. 2012; Kruger et al. 2012; Shimada et al. 2012) PubMed:29626319

Appears in Networks:

a(CHEBI:"methylene blue") decreases act(p(HGNC:MARK4), ma(kin)) View Subject | View Object

In 293T culture, MB decreased MARK4-mediated Tau phosphorylation in a dose dependent manner. MB down-regulates MARK4 protein level through ubiquitin-proteasome pathway and inhibition of MARK4 kinase activity in vitro. PubMed:23666762

Appears in Networks:

a(CHEBI:"methylene blue") increases deg(p(HGNC:MARK4)) View Subject | View Object

In 293T culture, MB decreased MARK4-mediated Tau phosphorylation in a dose dependent manner. MB down-regulates MARK4 protein level through ubiquitin-proteasome pathway and inhibition of MARK4 kinase activity in vitro. PubMed:23666762

Appears in Networks:

a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(Ac)) View Subject | View Object

Thus, K → Q substitutions within the critical PHF6* motif, in the apparent absence of other tau PTMs, appears sufficient to accelerate tau aggregation in vitro. PubMed:28287136

Appears in Networks:

a(CHEBI:"methylene blue") decreases complex(p(HGNC:APP), p(HGNC:HSD17B10)) View Subject | View Object

In mechanistic studies, it was proposed that methylene blue inhibits the Aβ-ABAD interaction and decreases mitochondrial dysfunction by decreasing the expression of ABAD levels, in addition to decreasing Aβ levels. PubMed:30444369

Appears in Networks:

a(CHEBI:"methylene blue") decreases path(HBP:"mitochondrial dysfunction") View Subject | View Object

In mechanistic studies, it was proposed that methylene blue inhibits the Aβ-ABAD interaction and decreases mitochondrial dysfunction by decreasing the expression of ABAD levels, in addition to decreasing Aβ levels. PubMed:30444369

Appears in Networks:

a(CHEBI:"methylene blue") decreases p(HGNC:HSD17B10) View Subject | View Object

In mechanistic studies, it was proposed that methylene blue inhibits the Aβ-ABAD interaction and decreases mitochondrial dysfunction by decreasing the expression of ABAD levels, in addition to decreasing Aβ levels. PubMed:30444369

Appears in Networks:

a(CHEBI:"methylene blue") decreases a(HBP:"amyloid-beta aggregates") View Subject | View Object

In mechanistic studies, it was proposed that methylene blue inhibits the Aβ-ABAD interaction and decreases mitochondrial dysfunction by decreasing the expression of ABAD levels, in addition to decreasing Aβ levels. PubMed:30444369

Appears in Networks:

a(CHEBI:"methylene blue") decreases p(HGNC:MAPT, pmod(HBP:misfolding)) View Subject | View Object

Methylene blue, a contrast agent that can reduce tau misfolding, has also been shown to induce macroautophagy, as indicated by elevated Beclin 1 and LC3-II levels and reduced tau and p62 levels in organotypic neuronal cultures and a mouse model of FTD [159] PubMed:29758300

Appears in Networks:

a(CHEBI:"methylene blue") increases bp(GO:macroautophagy) View Subject | View Object

Methylene blue, a contrast agent that can reduce tau misfolding, has also been shown to induce macroautophagy, as indicated by elevated Beclin 1 and LC3-II levels and reduced tau and p62 levels in organotypic neuronal cultures and a mouse model of FTD [159] PubMed:29758300

Appears in Networks:

a(CHEBI:"methylene blue") increases p(HGNC:BECN1) View Subject | View Object

Methylene blue, a contrast agent that can reduce tau misfolding, has also been shown to induce macroautophagy, as indicated by elevated Beclin 1 and LC3-II levels and reduced tau and p62 levels in organotypic neuronal cultures and a mouse model of FTD [159] PubMed:29758300

Appears in Networks:

a(CHEBI:"methylene blue") increases p(HGNC:MAP1LC3B) View Subject | View Object

Methylene blue, a contrast agent that can reduce tau misfolding, has also been shown to induce macroautophagy, as indicated by elevated Beclin 1 and LC3-II levels and reduced tau and p62 levels in organotypic neuronal cultures and a mouse model of FTD [159] PubMed:29758300

Appears in Networks:

a(CHEBI:"methylene blue") decreases p(HGNC:MAPT) View Subject | View Object

Methylene blue, a contrast agent that can reduce tau misfolding, has also been shown to induce macroautophagy, as indicated by elevated Beclin 1 and LC3-II levels and reduced tau and p62 levels in organotypic neuronal cultures and a mouse model of FTD [159] PubMed:29758300

Appears in Networks:

a(CHEBI:"methylene blue") decreases p(HGNC:SQSTM1) View Subject | View Object

Methylene blue, a contrast agent that can reduce tau misfolding, has also been shown to induce macroautophagy, as indicated by elevated Beclin 1 and LC3-II levels and reduced tau and p62 levels in organotypic neuronal cultures and a mouse model of FTD [159] PubMed:29758300

Appears in Networks:

a(CHEBI:"methylene blue") increases bp(GO:locomotion) View Subject | View Object

We supplemented the growth medium of syn- chronized L1 larvae (pro-aggregant strain) with 25 m M MB and measured their locomotion speed as day 1 young adults. This treatment led to 15% amelioration of locomotion (Sup- plementary Material, Fig. S6A). PubMed:22611162

Appears in Networks:
Annotations
MeSH
Tauopathies

a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") View Subject | View Object

At the biochemical level, MB treatment altered Tau solubility, shifting the equilibrium towards more soluble Tau and reduced detergent-insoluble Tau by  35% in the pro-aggregant strain (Fig. 8A, quantitation in 8B), con- sistent with its anti-aggregation properties (31). PubMed:22611162

Appears in Networks:

a(CHEBI:"methylene blue") decreases a(HBP:"Tau aggregates") View Subject | View Object

For example, Fatouros et al. (68) tested several tau-aggregation inhibitor compounds such as methylene blue, a rhodanine derivative (bb14), and a phenylthiazolyl hydrazide derivative (BSc3094), which reduce the insoluble tau and partially suppress the Unc phenotype. PubMed:29191965

Appears in Networks:

a(CHEBI:"methylene blue") positiveCorrelation bp(GO:locomotion) View Subject | View Object

For example, Fatouros et al. (68) tested several tau-aggregation inhibitor compounds such as methylene blue, a rhodanine derivative (bb14), and a phenylthiazolyl hydrazide derivative (BSc3094), which reduce the insoluble tau and partially suppress the Unc phenotype. PubMed:29191965

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.