complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases act(p(HGNC:HSD17B10))

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PubMed:30444369

However, it is well established that Aβ binding to ABAD induces a conformational change in the enzyme that prevents the binding of NAD + , preventing the enzyme performing its role in the oxidation of substrates, leading to changes in mitochondrial membrane permeability, which in turn has deleterious effects on mitochondrial enzymes.

Related Edges 1

• complex(p(HGNC:APP), p(HGNC:HSD17B10)) decreases complex(a(CHEBI:"NAD(+)"), p(HGNC:HSD17B10))

MeSH

Neurons

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