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Appears in Networks 2

In-Edges 5

Out-Edges 3

p(HGNC:PPP2R3A) increases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) View Subject | View Object

To gain full activity towards specific substrates, the PP2A core enzyme interacts with a variable regulatory subunit to form a heterotrimeric holoenzyme. The variable regulatory subunits consist of four families: B (also known as B55 or PR55), B′ (B56 or PR61), B′′ (PR48/PR72/PR130), and B′′′ (PR93/PR110), with at least 16 members in these families PubMed:19277525

p(HGNC:PPP2R3A) directlyIncreases complex(p(HGNC:PPP2CA), p(HGNC:PPP2R1A), p(HGNC:PPP2R3A)) View Subject | View Object

Except the B′′′ subunits, direct interactions between the PP2A core enzyme and the regulatory subunits have been demonstrated PubMed:19277525

p(HGNC:PPP2R3A) association p(INTERPRO:"EF-hand domain") View Subject | View Object

In fact, the B subunit is now known to contain multiple WD40 repeats [28], whereas B′′/PR72 is thought to contain two calcium-binding EF hands PubMed:19277525


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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.