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path(MESH:Thrombophilia)

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Entity

Name
Thrombophilia
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 5

a(MESH:"Cell-Derived Microparticles") positiveCorrelation path(MESH:Thrombophilia) View Subject | View Object

In this work, we were able to document a significant increase in RBCderived MPs, and a lesser increase in PMN- and platelet-derived MPs, in these patient s. This increase in MPs may lead to the thrombophilic state [15]. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

complex(a(CHEBI:"carbon monoxide"), a(CHEBI:heme), p(HGNC:FGA)) positiveCorrelation path(MESH:Thrombophilia) View Subject | View Object

It was determined that the patient’s plasmatic hypercoagulability was in part due to carboxyhemefibrinogen formation via a thrombelastographic method. PubMed:24553061

Appears in Networks:
Annotations
Text Location
Discussion

p(HGNC:HBB) positiveCorrelation path(MESH:Thrombophilia) View Subject | View Object

High free hemoglobin was shown in patients with primary Cys89Tyr mutation in CD59 (Table 1) and it has been suggested in several ways that free hemoglobin may serve as a major mechanism for thrombophilia. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Cell Ontology (CL)
neutrophil
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Results

path(HP:"Paroxysmal nocturnal hemoglobinuria") association path(MESH:Thrombophilia) View Subject | View Object

Inhibition of the terminal complement cascade by eculizumab (inhibits the cleavage of C5 into C5a und C5b and thus the formation of the membrane attack complex 8, MAC C5b-C9) for the treatment of hemolytic paroxymal nocturnal hemoglobinuria (PNH) significantly prevented PNH-related symptoms in patients including abnormal thrombophilia, red blood cell destruction, and the extent of hemolysis [76]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

path(MESH:Hemolysis) positiveCorrelation path(MESH:Thrombophilia) View Subject | View Object

Intravascular hemolysis is one thrombophilic mechanisms in PNH (reviewed by Hill et al. [14]). PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Cell Ontology (CL)
neutrophil
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

Out-Edges 5

path(MESH:Thrombophilia) positiveCorrelation complex(a(CHEBI:"carbon monoxide"), a(CHEBI:heme), p(HGNC:FGA)) View Subject | View Object

It was determined that the patient’s plasmatic hypercoagulability was in part due to carboxyhemefibrinogen formation via a thrombelastographic method. PubMed:24553061

Appears in Networks:
Annotations
Text Location
Discussion

path(MESH:Thrombophilia) positiveCorrelation p(HGNC:HBB) View Subject | View Object

High free hemoglobin was shown in patients with primary Cys89Tyr mutation in CD59 (Table 1) and it has been suggested in several ways that free hemoglobin may serve as a major mechanism for thrombophilia. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Cell Ontology (CL)
neutrophil
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Results

path(MESH:Thrombophilia) positiveCorrelation path(MESH:Hemolysis) View Subject | View Object

Intravascular hemolysis is one thrombophilic mechanisms in PNH (reviewed by Hill et al. [14]). PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
Cell Ontology (CL)
neutrophil
Cell Ontology (CL)
platelet
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

path(MESH:Thrombophilia) positiveCorrelation a(MESH:"Cell-Derived Microparticles") View Subject | View Object

In this work, we were able to document a significant increase in RBCderived MPs, and a lesser increase in PMN- and platelet-derived MPs, in these patient s. This increase in MPs may lead to the thrombophilic state [15]. PubMed:29929138

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Endothelium
MeSH
Hemoglobinuria, Paroxysmal
Text Location
Discussion

path(MESH:Thrombophilia) association path(HP:"Paroxysmal nocturnal hemoglobinuria") View Subject | View Object

Inhibition of the terminal complement cascade by eculizumab (inhibits the cleavage of C5 into C5a und C5b and thus the formation of the membrane attack complex 8, MAC C5b-C9) for the treatment of hemolytic paroxymal nocturnal hemoglobinuria (PNH) significantly prevented PNH-related symptoms in patients including abnormal thrombophilia, red blood cell destruction, and the extent of hemolysis [76]. PubMed:29956069

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Liver
MeSH
Sepsis
Text Location
Review

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.