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a(HBP:"alpha-3 beta-2 nAChR")

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Entity

Name
alpha-3 beta-2 nAChR
Namespace
HBP
Namespace Version
20181221
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/bd0996a28201cad363557315043c6392e31abf58/export/hbp-names.belns

Appears in Networks 3

albuquerque2009 v1.0.0

This file encodes the article Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function by Albuquerque et al, 2009

Up-regulation of Nicotinic Receptors by Nicotine Varies with Receptor Subtype v1.0.0

Naturally-expressed nicotinic acetylcholine receptor subtypes v1.0.0

In-Edges 8

a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") View Subject | View Object

For instance, prolonged exposure of HEK293 cells to saturating nicotine concentrations increased by 6- and 1.5-fold, respectively, the expression of alpha3beta2 and alpha3beta4 nAChRs.Similarly, while alpha4beta2 nAChRs upregulate strongly, alpha4beta4 nAChRs upregulate poorly in response to continuous exposure to nicotine. PubMed:19126755

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
HEK293
Text Location
Review

a(CHEBI:nicotine) increases a(HBP:"alpha-3 beta-2 nAChR") View Subject | View Object

At 37°C, the timecourse of the a6b2 and a3b2 up-regulation is essentially complete after 2 h, and no signifi- cant changes were observed with longer nicotine incubations. PubMed:18174175

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complex(a(CHEBI:epibatidine), a(HBP:"alpha-3 beta-2 nAChR")) hasComponent a(HBP:"alpha-3 beta-2 nAChR") View Subject | View Object

Appears in Networks:

complex(a(CHEBI:epibatidine), a(HBP:"alpha-3 beta-2 nAChR")) increases act(a(HBP:"alpha-3 beta-2 nAChR")) View Subject | View Object

We first assayed expression of a6b2 or a3b2 receptors by binding the agonist, 125 I-labeled epibatidine (Fig. 1, A and B), to stably transfected a6FLAGb2HA cells and transiently trans- fected a3FLAGb2HA cells. PubMed:18174175

Appears in Networks:

a(HBP:"kappa-Bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) View Subject | View Object

Other ‘‘a3b2-specific’’ antagonists, such as neuronal- or kappa- bungarotoxin and a-CtxPnIA, have also turned out to block a6*- nAChRs [129]. PubMed:21787755

Appears in Networks:

a(MESH:"alpha-conotoxin MII") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) View Subject | View Object

Initially, a-CtxMII was thought to be highly selective for a3b2*-nAChRs [124] and became a useful tool for investigating receptor structure [125]. PubMed:21787755

Appears in Networks:

a(MESH:"alpha-conotoxin PnIA") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) View Subject | View Object

Other ‘‘a3b2-specific’’ antagonists, such as neuronal- or kappa- bungarotoxin and a-CtxPnIA, have also turned out to block a6*- nAChRs [129]. PubMed:21787755

Appears in Networks:

a(MESH:"neuronal bungarotoxin") decreases act(a(HBP:"alpha-3 beta-2 nAChR")) View Subject | View Object

Other ‘‘a3b2-specific’’ antagonists, such as neuronal- or kappa- bungarotoxin and a-CtxPnIA, have also turned out to block a6*- nAChRs [129]. PubMed:21787755

Appears in Networks:

Out-Edges 1

a(HBP:"alpha-3 beta-2 nAChR") regulates sec(a(CHEBI:"gamma-aminobutyric acid")) View Subject | View Object

Also, Endo et al. [141] found naturally-expressed a3b2- and a6b2-nAChRs on superior colli- culus neurons, and these receptors are likely located on pre- synaptic terminals of GABAergic neurons where they modulate GABA release. PubMed:21787755

Appears in Networks:
Annotations
MeSH
GABAergic Neurons
MeSH
Presynaptic Terminals

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.