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p(HGNC:RIC3)

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Entity

Name
RIC3
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

Neural Systems Governed by Nicotinic Acetylcholine Receptors: Emerging Hypotheses v1.0.0

Chaperoning α7 neuronal nicotinic acetylcholine receptors v1.0.0

In-Edges 11

complex(p(FPLX:CHRN), p(HGNC:RIC3)) hasComponent p(HGNC:RIC3) View Subject | View Object

Appears in Networks:

complex(GO:"proteasome complex") regulates p(HGNC:RIC3) View Subject | View Object

Furthermore, the proteasome in- directly regulates synaptic transmission mediated by AChRs via regu- lation of RIC-3 [113]. PubMed:22040696

Appears in Networks:

complex(p(HGNC:CHRNA3), p(HGNC:RIC3)) hasComponent p(HGNC:RIC3) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA4), p(HGNC:RIC3)) hasComponent p(HGNC:RIC3) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNA7), p(HGNC:RIC3)) hasComponent p(HGNC:RIC3) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNB2), p(HGNC:RIC3)) hasComponent p(HGNC:RIC3) View Subject | View Object

Appears in Networks:

complex(p(HGNC:CHRNB4), p(HGNC:RIC3)) hasComponent p(HGNC:RIC3) View Subject | View Object

Appears in Networks:

complex(p(HGNC:RIC3), p(UNIPROT:P34371)) hasComponent p(HGNC:RIC3) View Subject | View Object

Appears in Networks:

composite(p(HGNC:HTR3A), p(HGNC:RIC3)) hasComponent p(HGNC:RIC3) View Subject | View Object

Appears in Networks:

path(MESH:"Bipolar Disorder") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) View Subject | View Object

Interestingly, levels of RIC-3 mRNA are elevat- ed in postmortem brains of individuals with bipolar disorder and schizophrenia [181], and a link has been suggested between defi- cient RIC-3 mediated chaperoning of an AChR subunit and individ- uals with bipolar disorder and psychotic symptoms [181]. PubMed:22040696

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Psychotic Disorders") negativeCorrelation act(p(HGNC:RIC3), ma(chap)) View Subject | View Object

Interestingly, levels of RIC-3 mRNA are elevat- ed in postmortem brains of individuals with bipolar disorder and schizophrenia [181], and a link has been suggested between defi- cient RIC-3 mediated chaperoning of an AChR subunit and individ- uals with bipolar disorder and psychotic symptoms [181]. PubMed:22040696

Appears in Networks:
Annotations
MeSH
Brain

Out-Edges 16

p(HGNC:RIC3) increases act(p(FPLX:CHRN)) View Subject | View Object

Resistance to inhibitor of cholinesterase-3 (RIC-3) is required for nAChR function in C. elegans (Nguyen et al., 1995) PubMed:28445721

Appears in Networks:

p(HGNC:RIC3) increases act(p(FPLX:CHRN)) View Subject | View Object

Whereas RIC-3 can enhance function of certain mammalian nAChRs, RIC-3 is not essential (Koperniak et al., 2013) PubMed:28445721

Appears in Networks:

p(HGNC:RIC3) increases act(p(FPLX:CHRN)) View Subject | View Object

In C. elegans, RIC-3 protein is essential for nAChR function (Nguyen et al., 1995), and mammalian RIC-3 has modest and mixed effects on nAChRs (Halevi et al., 2003; Millar, 2008) PubMed:28445721

Appears in Networks:

p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"nicotinic receptor alpha3beta2")) View Subject | View Object

For alpha7 and alpha3beta2, RIC-3 did not enable detectable [3H]epibatidine binding, yet RIC-3 profoundly augmented the effects of NACHO on [3H]epibatidine binding to either receptor subtype (Figures 3A and S1A) PubMed:28445721

Appears in Networks:

p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) View Subject | View Object

For alpha7 and alpha3beta2, RIC-3 did not enable detectable [3H]epibatidine binding, yet RIC-3 profoundly augmented the effects of NACHO on [3H]epibatidine binding to either receptor subtype (Figures 3A and S1A) PubMed:28445721

Appears in Networks:

p(HGNC:RIC3) increases surf(a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) View Subject | View Object

As previously reported using fluorescently labeled alpha-bungarotoxin (Gu et al., 2016), NACHO enabled formation of assembled surface alpha7 receptors, and RIC-3 further enhanced this (Figures 3E and 3F) PubMed:28445721

Appears in Networks:

act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) View Subject | View Object

More re- cently, the transmembrane protein resistant to inhibitors of cholines- terase (RIC-3), originally identified in Caenorhabditis elegans, has been classed as a much more selective chaperone of the AChR [71,107–112]. PubMed:22040696

Appears in Networks:

p(HGNC:RIC3) increases act(p(FPLX:CHRN)) View Subject | View Object

Co-expression with RIC-3 was shown to be required for AChR ac- tivity in C. elegans body muscles and for enhanced AChR activity in Xenopus oocytes [110,112]. PubMed:22040696

Appears in Networks:

act(p(HGNC:RIC3), ma(chap)) increases p(FPLX:CHRN) View Subject | View Object

Interestingly, levels of RIC-3 mRNA are elevat- ed in postmortem brains of individuals with bipolar disorder and schizophrenia [181], and a link has been suggested between defi- cient RIC-3 mediated chaperoning of an AChR subunit and individ- uals with bipolar disorder and psychotic symptoms [181]. PubMed:22040696

Appears in Networks:
Annotations
MeSH
Brain

p(HGNC:RIC3) increases bp(GO:"synaptic transmission, cholinergic") View Subject | View Object

In C. elegans, RIC-3 is necessary for synaptic transmission mediated by neuronal AChRs but not by other LGICs [71,77,109]. PubMed:22040696

Appears in Networks:

p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA3), p(HGNC:CHRNB4))) View Subject | View Object

In contrast, RIC-3 caused a marked inhibition of functional responses with hetero- meric α3β4 and α4β2 AChRs in Xenopus oocytes [109]. PubMed:22040696

Appears in Networks:

p(HGNC:RIC3) decreases act(complex(p(HGNC:CHRNA4), p(HGNC:CHRNB2))) View Subject | View Object

In contrast, RIC-3 caused a marked inhibition of functional responses with hetero- meric α3β4 and α4β2 AChRs in Xenopus oocytes [109]. PubMed:22040696

Appears in Networks:

p(HGNC:RIC3) increases p(HGNC:CHRNA9) View Subject | View Object

Osman et al. [122] find that RIC-3 expression increases the total amount of α9 AChR in CL4 cells, supporting the view that RIC-3 regulates AChR trafficking by increasing the number of mature or correctly folded receptor subunits reaching the cell surface. PubMed:22040696

Appears in Networks:

p(HGNC:RIC3) increases p(HGNC:CHRNA7) View Subject | View Object

It is noteworthy that RIC-3 has been shown to increase α7 AChR heterologous expression both in X. laevis oocytes and in HEK-293, CHO and SHE-P1 mammalian cell lines [66,71,77,107–112,119,125]. PubMed:22040696

Appears in Networks:

act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Bipolar Disorder") View Subject | View Object

Interestingly, levels of RIC-3 mRNA are elevat- ed in postmortem brains of individuals with bipolar disorder and schizophrenia [181], and a link has been suggested between defi- cient RIC-3 mediated chaperoning of an AChR subunit and individ- uals with bipolar disorder and psychotic symptoms [181]. PubMed:22040696

Appears in Networks:
Annotations
MeSH
Brain

act(p(HGNC:RIC3), ma(chap)) negativeCorrelation path(MESH:"Psychotic Disorders") View Subject | View Object

Interestingly, levels of RIC-3 mRNA are elevat- ed in postmortem brains of individuals with bipolar disorder and schizophrenia [181], and a link has been suggested between defi- cient RIC-3 mediated chaperoning of an AChR subunit and individ- uals with bipolar disorder and psychotic symptoms [181]. PubMed:22040696

Appears in Networks:
Annotations
MeSH
Brain

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.