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complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor"))

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Components

Appears in Networks 1

NACHO Mediates Nicotinic Acetylcholine Receptor Function throughout the Brain v1.0.0

In-Edges 3

a(MESH:Bungarotoxins) decreases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) View Subject | View Object

Strikingly, we found that alpha-bungarotoxin did not completely displace [3H]epibatidine binding to alpha7 receptors with NACHO (Figure 3B) PubMed:28445721

Appears in Networks:

p(HGNC:RIC3) causesNoChange complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) View Subject | View Object

For alpha7 and alpha3beta2, RIC-3 did not enable detectable [3H]epibatidine binding, yet RIC-3 profoundly augmented the effects of NACHO on [3H]epibatidine binding to either receptor subtype (Figures 3A and S1A) PubMed:28445721

Appears in Networks:

act(p(HGNC:TMEM35A), ma(chap)) increases complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) View Subject | View Object

In membranes from alpha7-transfected cells, [3H]epibatidine binding absolutely required NACHO (Figure 2A), which fits with an essential role for NACHO in alpha7 assembly PubMed:28445721

Appears in Networks:

Out-Edges 2

complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) hasComponent a(CHEBI:epibatidine) View Subject | View Object

Appears in Networks:

complex(a(CHEBI:epibatidine), a(MESH:"alpha7 Nicotinic Acetylcholine Receptor")) hasComponent a(MESH:"alpha7 Nicotinic Acetylcholine Receptor") View Subject | View Object

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.