1. Catalog
  2. Nodes
  3. p(HGNC:TARDBP)

p(HGNC:TARDBP)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
TARDBP
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 6

The Biology of Proteostasis in Aging and Disease v1.0.0

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 10

a(CHEBI:fluphenazine) decreases p(HGNC:TARDBP) View Subject | View Object

An in silico screen based on the structure of 10-NCP, an Akt inhibitor that potently induces autophagy (144), identified the molecules FPZ and MTM as potent activators of autophagic flux and clearance of TDP-43 in mammalian cells (145). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

a(CHEBI:methotrimeprazine) decreases p(HGNC:TARDBP) View Subject | View Object

An in silico screen based on the structure of 10-NCP, an Akt inhibitor that potently induces autophagy (144), identified the molecules FPZ and MTM as potent activators of autophagic flux and clearance of TDP-43 in mammalian cells (145). PubMed:25784053

Appears in Networks:
Annotations
Cell Ontology (CL)
motor neuron

a(PUBCHEM:675434) decreases p(HGNC:TARDBP) View Subject | View Object

Treatment with IU1 reduced the levels of Tau, TDP-43, and ataxin-3 in MEFs in a USP14-dependent manner and independently of changes in proteasome levels or composition (147). PubMed:25784053

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
MEF cell line
Cell Ontology (CL)
motor neuron

p(HGNC:USP14) decreases deg(p(HGNC:TARDBP)) View Subject | View Object

The DUB USP14 suppresses turnover of Tau and TDP-43 in mouse embryonic fibroblasts (MEFs) by impairing the protea-some; PubMed:25784053

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
MEF cell line
Cell Ontology (CL)
motor neuron

bp(GO:"chaperone-mediated autophagy") increases deg(p(HGNC:TARDBP)) View Subject | View Object

Tau, α-synuclein and TDP43 are substrates for CMA degradation, as are amyloid precursor protein (APP) but not amyloid-β fragment 42 (Aβ42) itself 3,45–47,48 . PubMed:30116051

Appears in Networks:

p(HGNC:TARDBP, pmod(Ph, Ser, 409)) increases act(p(HGNC:TARDBP)) View Subject | View Object

We recently found that overexpression of TDP-43 enhances tau exon 10 inclusion and tau mRNA instability. Overexpression of PP1α and PP1γ, but not PP1β, suppressed TDP-43 phosphorylation at Ser403/404 and Ser409/410 and TDP-43-induced tau exon 10 inclusion. PubMed:29334120

Appears in Networks:

p(HGNC:TARDBP, pmod(Ph, Ser, 410)) increases act(p(HGNC:TARDBP)) View Subject | View Object

We recently found that overexpression of TDP-43 enhances tau exon 10 inclusion and tau mRNA instability. Overexpression of PP1α and PP1γ, but not PP1β, suppressed TDP-43 phosphorylation at Ser403/404 and Ser409/410 and TDP-43-induced tau exon 10 inclusion. PubMed:29334120

Appears in Networks:

a(CHEBI:"amyloid-beta") increases p(HGNC:TARDBP) View Subject | View Object

Although exact relations remain unknown, it was reported that Aβ can induce a cascade that results in phosphorylation and subsequent deposition of TDP-43 in the cytosol [70] PubMed:29758300

Appears in Networks:
Annotations
MeSH
Cytosol

path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(GO:"inclusion body")) View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(HBP:"dystrophic neurite")) View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

Out-Edges 12

act(p(HGNC:TARDBP)) increases p(HBP:"4R tau") View Subject | View Object

We recently found that overexpression of TDP-43 enhances tau exon 10 inclusion and tau mRNA instability. Overexpression of PP1α and PP1γ, but not PP1β, suppressed TDP-43 phosphorylation at Ser403/404 and Ser409/410 and TDP-43-induced tau exon 10 inclusion. PubMed:29334120

Appears in Networks:

p(HGNC:TARDBP) hasVariant p(HGNC:TARDBP, pmod(Ph)) View Subject | View Object

Appears in Networks:

p(HGNC:TARDBP) hasVariant p(HGNC:TARDBP, pmod(Ph, Ser, 397)) View Subject | View Object

Appears in Networks:

p(HGNC:TARDBP) hasVariant p(HGNC:TARDBP, pmod(Ph, Ser, 403)) View Subject | View Object

Appears in Networks:

p(HGNC:TARDBP) hasVariant p(HGNC:TARDBP, pmod(Ph, Ser, 404)) View Subject | View Object

Appears in Networks:

p(HGNC:TARDBP) hasVariant p(HGNC:TARDBP, pmod(Ph, Ser, 409)) View Subject | View Object

Appears in Networks:

p(HGNC:TARDBP) hasVariant p(HGNC:TARDBP, pmod(Ph, Ser, 410)) View Subject | View Object

Appears in Networks:

p(HGNC:TARDBP) hasVariant p(HGNC:TARDBP, pmod(HBP:misfolding)) View Subject | View Object

Appears in Networks:

p(HGNC:TARDBP) hasVariant p(HGNC:TARDBP, pmod(Ub)) View Subject | View Object

Appears in Networks:

p(HGNC:TARDBP) hasVariant p(HGNC:TARDBP, pmod(HBP:misfolded)) View Subject | View Object

Appears in Networks:

p(HGNC:TARDBP, loc(GO:"inclusion body")) association path(MESH:"Frontotemporal Lobar Degeneration") View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

p(HGNC:TARDBP, loc(HBP:"dystrophic neurite")) association path(MESH:"Frontotemporal Lobar Degeneration") View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.