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  3. path(MESH:"Frontotemporal Lobar Degeneration")

path(MESH:"Frontotemporal Lobar Degeneration")

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Entity

Name
Frontotemporal Lobar Degeneration
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 3

The Ubiquitin–Proteasome System and the Autophagic–Lysosomal System in Alzheimer Disease v1.0.0

Tau in physiology and pathology v1.0.0

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 6

p(HGNC:TARDBP, pmod(Ub)) positiveCorrelation path(MESH:"Frontotemporal Lobar Degeneration") View Subject | View Object

In this regard, the entity of frontotemporal lobar degeneration (FTLD) with Ub-positive/tau-negative inclusions was described later, and TDP43 was identified as the ubiquitinated protein in both this disorder and ALS (Neuman et al. 2006). PubMed:22908190

Appears in Networks:

p(HGNC:FUS) association path(MESH:"Frontotemporal Lobar Degeneration") View Subject | View Object

Indeed, knockdown of FUS increases the expression of the 2N and 4R tau isoforms, providing a possible link between frontotemporal lobar degeneration-FUS (FTLDFUS; a subtype of FTD characterized by FUS inclusions in neurons and glia) and FTLD-tau (a tauopathy). PubMed:26631930

Appears in Networks:

p(HGNC:TARDBP, loc(GO:"inclusion body")) association path(MESH:"Frontotemporal Lobar Degeneration") View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

p(HGNC:TARDBP, loc(HBP:"dystrophic neurite")) association path(MESH:"Frontotemporal Lobar Degeneration") View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Psychotic Disorders") association path(MESH:"Frontotemporal Lobar Degeneration") View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:Catatonia) association path(MESH:"Frontotemporal Lobar Degeneration") View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

Out-Edges 6

path(MESH:"Frontotemporal Lobar Degeneration") positiveCorrelation p(HGNC:TARDBP, pmod(Ub)) View Subject | View Object

In this regard, the entity of frontotemporal lobar degeneration (FTLD) with Ub-positive/tau-negative inclusions was described later, and TDP43 was identified as the ubiquitinated protein in both this disorder and ALS (Neuman et al. 2006). PubMed:22908190

Appears in Networks:

path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:FUS) View Subject | View Object

Indeed, knockdown of FUS increases the expression of the 2N and 4R tau isoforms, providing a possible link between frontotemporal lobar degeneration-FUS (FTLDFUS; a subtype of FTD characterized by FUS inclusions in neurons and glia) and FTLD-tau (a tauopathy). PubMed:26631930

Appears in Networks:

path(MESH:"Frontotemporal Lobar Degeneration") association path(MESH:"Psychotic Disorders") View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Frontotemporal Lobar Degeneration") association path(MESH:Catatonia) View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(GO:"inclusion body")) View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

path(MESH:"Frontotemporal Lobar Degeneration") association p(HGNC:TARDBP, loc(HBP:"dystrophic neurite")) View Subject | View Object

Remarkably, a very recent neuropathological examination provided evidence for TDP-43-positive cytosolic inclusions and dystrophic neurites in the brain of a patient diagnosed with FTLD presenting brief psychotic episodes and catatonia, which is a syndrome related to schizophrenia PubMed:30061532

Appears in Networks:
Annotations
MeSH
Brain

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.