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bp(HBP:HBP00073)

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Entity

Name
HBP00073
Namespace
HBP
Namespace Version
20181029
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 4

Amyloid Precursor Protein Trafficking, Processing, and Function v1.0.0

Amyloid Precursor Protein Trafficking, Processing, and Function by Thinakaran, et al., 2008

APP processing in Alzheimer's disease v1.0.1

APP processing in Alzheimer's disease

Proteolytic processing of Alzeimer's beta-amyloid precursor protein v1.0.1

Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing v1.0.0

In-Edges 13

p(HGNC:APBA1) regulates bp(HBP:HBP00073) View Subject | View Object

Overexpression of Mint1, Mint2, or Fe65 causes reduction in Aβ generation and deposition in the brains of transgenic mice, strongly suggesting a physiological role for these adaptors in regulating APP processing in the nervous tis- sue (17). PubMed:18650430

Appears in Networks:
Annotations
Confidence
Medium

p(HGNC:APBA2) regulates bp(HBP:HBP00073) View Subject | View Object

Overexpression of Mint1, Mint2, or Fe65 causes reduction in Aβ generation and deposition in the brains of transgenic mice, strongly suggesting a physiological role for these adaptors in regulating APP processing in the nervous tis- sue (17). PubMed:18650430

Appears in Networks:
Annotations
Confidence
Medium

p(HGNC:APBB1) regulates bp(HBP:HBP00073) View Subject | View Object

Overexpression of Mint1, Mint2, or Fe65 causes reduction in Aβ generation and deposition in the brains of transgenic mice, strongly suggesting a physiological role for these adaptors in regulating APP processing in the nervous tis- sue (17). PubMed:18650430

Appears in Networks:
Annotations
Confidence
Medium

p(HGNC:RAB6A) association bp(HBP:HBP00073) View Subject | View Object

Rab6, a member of the GTP-binding protein family of membrane trafficking regulators, is implicated in protein transport along biosynthetic and endocytic pathways and has also been found to affect APP processing PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) regulates bp(HBP:HBP00073) View Subject | View Object

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

complex(p(HGNC:APP), p(HGNC:ITM2B)) regulates bp(HBP:HBP00073) View Subject | View Object

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

complex(p(HGNC:APP), p(HGNC:NTN1)) regulates bp(HBP:HBP00073) View Subject | View Object

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

complex(p(HGNC:APP), p(HGNC:RTN4R)) regulates bp(HBP:HBP00073) View Subject | View Object

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

complex(p(HGNC:APP), p(HGNC:SPON1)) regulates bp(HBP:HBP00073) View Subject | View Object

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HBP:HBP00071, pmod(Ph, Ser, 665)) association bp(HBP:HBP00073) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HBP:HBP00071, pmod(Ph, Thr, 654)) association bp(HBP:HBP00073) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HBP:HBP00071, pmod(Ph, Thr, 668)) association bp(HBP:HBP00073) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

p(HGNC:LRRK2, var("?")) association bp(HBP:HBP00073) View Subject | View Object

Some of these lead to an impairment of the ALN owing to reduced activation of beclin 1; another repercussion may be altered process- ing of APP, providing an unexpected link to AD 69,71–73 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Parkinson Disease

Out-Edges 5

bp(HBP:HBP00073) association p(HGNC:RAB6A) View Subject | View Object

Rab6, a member of the GTP-binding protein family of membrane trafficking regulators, is implicated in protein transport along biosynthetic and endocytic pathways and has also been found to affect APP processing PubMed:21214928

Appears in Networks:
Annotations
MeSH
Endosomes
Confidence
High
MeSH
Hippocampus
MeSH
Down Syndrome

bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 654)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Thr, 668)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

bp(HBP:HBP00073) association p(HBP:HBP00071, pmod(Ph, Ser, 665)) View Subject | View Object

Such phosphorylation may affect APP processing or the binding of AICD-interacting proteins, thus affecting the function of AICD (Gandy et al. 1988; Suzuki et al. 1994; Iijima et al. 2000; Inomata et al. 2003) PubMed:22122372

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons

bp(HBP:HBP00073) association p(HGNC:LRRK2, var("?")) View Subject | View Object

Some of these lead to an impairment of the ALN owing to reduced activation of beclin 1; another repercussion may be altered process- ing of APP, providing an unexpected link to AD 69,71–73 . PubMed:30116051

Appears in Networks:
Annotations
MeSH
Parkinson Disease

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.