complex(p(HGNC:APP), p(HGNC:ITM2B)) regulates bp(HBP:HBP00073)

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PubMed:22122372

Several studies have reported that certain ligands, including Abeta, F-spondin, Nogo- 66, netrin-1 and BRI2, bind to the extracellular domain of APP, resulting in modulated APP processing and sequential downstream signals (Lorenzo et al. 2000; Lu et al. 2003b; Ho and Sudhof 2004; Park et al. 2006; Lourenco et al. 2009; Matsuda et al. 2009; Zheng and Koo 2011)

Related Edges 4

• complex(a(CHEBI:"amyloid-beta"), p(HGNC:APP)) regulates bp(HBP:HBP00073)
• complex(p(HGNC:APP), p(HGNC:NTN1)) regulates bp(HBP:HBP00073)
• complex(p(HGNC:APP), p(HGNC:RTN4R)) regulates bp(HBP:HBP00073)
• complex(p(HGNC:APP), p(HGNC:SPON1)) regulates bp(HBP:HBP00073)

Confidence

High

MeSH

Neurons

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

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