Provenance

Upload
charles.hoyt@scai.fraunhofer.de at 2018-04-03 14:50:15
Authors
Daniel Domingo-Fernandez et. al
Contact
None
License
Private Ownership to Fraunhofer Institute SCAI
Number Nodes
67
Number Edges
144
Number Components
6
Network Density
0.0325645
Average Degree
2.14925
Number Citations
26
Number BEL Errors
0

Content Statistics

Network Overlap

The node-based overlap between this network and other networks is calculated as the Szymkiewicz-Simpson coefficient of their respective nodes. Up to the top 10 are shown below.

Network Overlap
BEL Framework Large Corpus Document v20170611 49%
Colorectal Cancer Model v2.0.6 22%
CRC_combined v1.1 20%
Selventa Protein Families Definitions v20150611 17%
Notch-2.0-Hs v2.0 17%
BEL Framework Small Corpus Document v20150611 14%
CRC_combined.bel v1.0 14%
fc34ba14-6a91-4142-811b-cacad7ad64ce_3150.txt v1.0 12%
NeuroMMSig AD Reactive oxygen species subgraph v5.0.4 11%
NeuroMMSig AD Low density lipoprotein subgraph v5.0.4 11%

Sample Edges

p(HGNC:STAT3, pmod(Ph)) increases bp(GOBP:"glial cell differentiation")

Recently, He et al. proposed that the Jak/STAT pathway is central to the gliogenic machinery and postulated a framework for understanding the control of gliogenesis during development (He et al., 2005). Treatment with sAPP increased phosphorylation of STAT3, which was suppressed when treated with L-685,458 (Fig 5C), indicating existence of crosstalk between the Notch and Jak/STAT pathway in APP-induced glial differentiation. PubMed:20883690

Annotations
NeuroMMSigDB
JAK-STAT signaling subgraph
NeuroMMSigDB
Notch signaling subgraph

p(HGNC:STAT3, pmod(Ph)) increases act(p(HGNC:NOTCH3))

Recently, He et al. proposed that the Jak/STAT pathway is central to the gliogenic machinery and postulated a framework for understanding the control of gliogenesis during development (He et al., 2005). Treatment with sAPP increased phosphorylation of STAT3, which was suppressed when treated with L-685,458 (Fig 5C), indicating existence of crosstalk between the Notch and Jak/STAT pathway in APP-induced glial differentiation. PubMed:20883690

Annotations
NeuroMMSigDB
JAK-STAT signaling subgraph
NeuroMMSigDB
Notch signaling subgraph

p(HGNC:STAT3, pmod(Ph)) increases act(p(HGNC:NOTCH1))

Recently, He et al. proposed that the Jak/STAT pathway is central to the gliogenic machinery and postulated a framework for understanding the control of gliogenesis during development (He et al., 2005). Treatment with sAPP increased phosphorylation of STAT3, which was suppressed when treated with L-685,458 (Fig 5C), indicating existence of crosstalk between the Notch and Jak/STAT pathway in APP-induced glial differentiation. PubMed:20883690

Annotations
NeuroMMSigDB
JAK-STAT signaling subgraph
NeuroMMSigDB
Notch signaling subgraph

p(HGNC:STAT3, pmod(Ph)) increases act(p(HGNC:NOTCH2))

Recently, He et al. proposed that the Jak/STAT pathway is central to the gliogenic machinery and postulated a framework for understanding the control of gliogenesis during development (He et al., 2005). Treatment with sAPP increased phosphorylation of STAT3, which was suppressed when treated with L-685,458 (Fig 5C), indicating existence of crosstalk between the Notch and Jak/STAT pathway in APP-induced glial differentiation. PubMed:20883690

Annotations
NeuroMMSigDB
JAK-STAT signaling subgraph
NeuroMMSigDB
Notch signaling subgraph

p(HGNC:STAT3, pmod(Ph)) increases act(p(HGNC:NOTCH4))

Recently, He et al. proposed that the Jak/STAT pathway is central to the gliogenic machinery and postulated a framework for understanding the control of gliogenesis during development (He et al., 2005). Treatment with sAPP increased phosphorylation of STAT3, which was suppressed when treated with L-685,458 (Fig 5C), indicating existence of crosstalk between the Notch and Jak/STAT pathway in APP-induced glial differentiation. PubMed:20883690

Annotations
NeuroMMSigDB
JAK-STAT signaling subgraph
NeuroMMSigDB
Notch signaling subgraph

Sample Nodes

a(CHEBI:resveratrol)

In-Edges: 15 | Out-Edges: 216 | Explore Neighborhood | Download JSON

bp(GOBP:"apoptotic process")

In-Edges: 916 | Out-Edges: 234 | Classes: 1 | Children: 2 | Explore Neighborhood | Download JSON

path(MESHD:"Alzheimer Disease")

In-Edges: 2116 | Out-Edges: 2040 | Classes: 4 | Children: 2 | Explore Neighborhood | Download JSON

bp(GOBP:neurogenesis)

In-Edges: 151 | Out-Edges: 58 | Explore Neighborhood | Download JSON

p(HGNC:APP)

In-Edges: 961 | Out-Edges: 647 | Classes: 2 | Explore Neighborhood | Download JSON

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of the open source project, PyBEL. Please feel free to contact us here to give us feedback or report any issues.