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path(MESH:Pain)

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Entity

Name
Pain
Namespace
mesh
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/mesh-names.belns

Appears in Networks 3

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors. v1.0.0

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

a(MESH:Conotoxins) decreases path(MESH:Pain) View Subject | View Object

In vivo, these α-conotoxins display potent alleviation of allopathic pain239,242,243 (and additionally reveal an endogeneous ACh activation of lymphocytes through α9α10 nAChRs, which are inhibited by these α-conotoxins). PubMed:19721446

Appears in Networks:
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Text Location
Review

p(MESH:"Receptors, Nicotinic") association path(MESH:Pain) View Subject | View Object

nAChRs contribute to cognitive function, and changes in their number and/or func- tion are associated with various pathological conditions such as cognitive disorders, anxiety, depression, Alzheimer’s and Parkinson’s disease, pain and epilepsy PubMed:28901280

Appears in Networks:

a(CHEBI:heme) positiveCorrelation path(MESH:Pain) View Subject | View Object

The released heme can activate the innate immune pattern recognition receptor toll-like receptor 4 (TLR4) on inflammatory cells, platelets and endothelium, promoting a pro-inflammatory and pro-coagulant phenotype, ultimately leading to vaso-occlusion, ischemia-reperfusion physiology, tissue injury, and pain in murine models of SCD [5, 7±10]. PubMed:29694434

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Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Introduction

path(MESH:"Osteoarthritis, Knee") positiveCorrelation path(MESH:Pain) View Subject | View Object

Knee osteoarthritis (OA) is the most common joint disease and is a major cause of pain and disability in the older population worldwide (Liu et al., 2015). PubMed:30505280

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Annotations
Text Location
Introduction

Out-Edges 3

path(MESH:Pain) association p(MESH:"Receptors, Nicotinic") View Subject | View Object

nAChRs contribute to cognitive function, and changes in their number and/or func- tion are associated with various pathological conditions such as cognitive disorders, anxiety, depression, Alzheimer’s and Parkinson’s disease, pain and epilepsy PubMed:28901280

Appears in Networks:

path(MESH:Pain) positiveCorrelation a(CHEBI:heme) View Subject | View Object

The released heme can activate the innate immune pattern recognition receptor toll-like receptor 4 (TLR4) on inflammatory cells, platelets and endothelium, promoting a pro-inflammatory and pro-coagulant phenotype, ultimately leading to vaso-occlusion, ischemia-reperfusion physiology, tissue injury, and pain in murine models of SCD [5, 7±10]. PubMed:29694434

Appears in Networks:
Annotations
MeSH
Blood Platelets
MeSH
Anemia, Sickle Cell
Text Location
Introduction

path(MESH:Pain) positiveCorrelation path(MESH:"Osteoarthritis, Knee") View Subject | View Object

Knee osteoarthritis (OA) is the most common joint disease and is a major cause of pain and disability in the older population worldwide (Liu et al., 2015). PubMed:30505280

Appears in Networks:
Annotations
Text Location
Introduction

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BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.