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  3. p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile"))

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile"))

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
App
Namespace
mgi
Namespace Version
20181021
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/f2f993e599694ab5ce989cc39d789a499f75db99/external/mgi-names.belns

Appears in Networks 1

A role for b2* nicotinic receptors in a model of local amyloid pathology induced in dentate gyrus v1.0.0

In-Edges 3

composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrna7)) hasComponent p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) View Subject | View Object

Appears in Networks:

p(MGI:App) hasVariant p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) View Subject | View Object

Appears in Networks:

composite(p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")), p(MGI:Chrnb2)) hasComponent p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) View Subject | View Object

Appears in Networks:

Out-Edges 11

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") View Subject | View Object

However, the analysis of the recognition percentage for the same set of data showed that GFP-WT spent significantly more time exploring the novel object compared with APP-WT (p = 0.0032; Fig. 2E), suggesting the presence of a memory deficit in the APP-WT group. PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") View Subject | View Object

Hence, the transduction of hAPP-SLA in DG induces recognition memory deficits as supported by NPR and NOR tasks PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases path(MESH:"Memory Disorders") View Subject | View Object

Similarly, in the NOR task (15 months p.i.), both the GFP-beta2 and the APP-beta2 displayed higher exploration of the novel object (p < 0.0001 and p = 0.0001, respectively; Fig. 4C and D), with no differences between the 2 groups in the recognition index (p = 0.7; Fig. 4E), meaning that beta2 mice injected with hAPP-SLA did not exhibit the recognition memory deficit observed in APP-WT PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases bp(GO:locomotion) View Subject | View Object

The locomotor behavior during the NOR habituation phase was measured by the total distance traveled: APP-WT showed higher locomotor activity compared with GFP-WT (p = 0.0027; Fig. 2F) PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange path(MESH:Anxiety) View Subject | View Object

We finally measured anxiety levels using the LDB paradigm. No differences were observed between both groups for the index of time spent in the lit compartment (p = 0.7) as well as for the number of transitions (p = 0.2; Fig. 2GeH) PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"microglial cell activation") View Subject | View Object

We did not detect any glia or microglia activation in WT-APP (Fig. 3C and F) compared with WT-GFP (Fig. 3B and E), meaning that the neuroinflammation does not play a role in the memory deficit we observed PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange act(a(MESH:Neuroglia)) View Subject | View Object

We did not detect any glia or microglia activation in WT-APP (Fig. 3C and F) compared with WT-GFP (Fig. 3B and E), meaning that the neuroinflammation does not play a role in the memory deficit we observed PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) causesNoChange bp(GO:"inflammatory response") View Subject | View Object

In addition, viral transduction did not induce any neuroinflammation, as shown in WT noninjected mice (Fig. 3A and D) PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) View Subject | View Object

The presence of oligomeric Abeta in APP-WT was confirmed with the antibody VHH 31-1, specific for oligomeric forms of Abeta (Lafaye et al., 2009) PubMed:27522251

Appears in Networks:

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) View Subject | View Object

Abeta was mainly found in the polymorphic layer of the DG (Fig. 6, arrows) PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

p(MGI:App, var("p.Lys670Asn"), var("p.Met671Leu"), var("p.Thr714Ile"), var("p.Val717Ile")) increases a(HBP:HBP00022) View Subject | View Object

Abeta intracellular accumulation in DG polymorphic layer was also confirmed with the rat monoclonal 7H3D6 antibody, also specific for oligomeric Abeta (Kumar et al., 2013) (Fig. 7, arrow) PubMed:27522251

Appears in Networks:
Annotations
MeSH
Dentate Gyrus

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.