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bp(GO:"metabolic process")

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Entity

Name
metabolic process
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 3

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

Alzheimer’s disease and the autophagic-lysosomal system v1.0.0

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection v1.0.0

In-Edges 5

bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") View Subject | View Object

Transcriptomic analyses of NFT-containing neurons microdissected from postmortem AD brain revealed an expression profile consistent with cellular senescence. This complex stress response induces aberrant cell cycle activity, adaptations to maintain survival, cellular remodeling, and metabolic dysfunction PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Alzheimer Disease

bp(GO:"cellular senescence") decreases bp(GO:"metabolic process") View Subject | View Object

This complex stress response induces a near permanent cell cycle arrest, adaptations to maintain survival, cellular remodeling, metabolic dysfunction and disruption to surrounding tissue to the secretion of toxic molecules (Childs et al., 2016) PubMed:30126037

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Brain
MeSH
Alzheimer Disease

p(HGNC:TREM2) increases bp(GO:"metabolic process") View Subject | View Object

Recent work by Ulland et al. has also discovered an additional function of TREM2 in the maintenance of microglial macroautophagy and metabolism PubMed:29758300

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell

p(HGNC:TREM2) increases bp(GO:"metabolic process") View Subject | View Object

TREM2 deficiency in an AD mouse model results in suppressed metabolic function in microglia through the dampening of the mTOR signaling pathway, which subsequently elicits a compensatory autophagic response to address the metabolic defect [109]. PubMed:29758300

Appears in Networks:
Annotations
Cell Ontology (CL)
microglial cell
MeSH
Alzheimer Disease

bp(GO:autophagy) regulates bp(GO:"metabolic process") View Subject | View Object

Autophagy is an evolutionarily conserved process whose primary task in lower organisms is the maintenance of metabolic homeostasis in the face of changing nutrient availability [8]. PubMed:18930136

Appears in Networks:

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.