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p(MGI:Cdkn1a)

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Entity

Name
Cdkn1a
Namespace
MGI
Namespace Version
20170725
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mgi-mouse-genes/mgi-mouse-genes-20170725.belns

Appears in Networks 1

Tau protein aggregation is associated with cellular senescence in the brain v1.0.0

In-Edges 2

bp(GO:"cellular senescence") increases p(MGI:Cdkn1a) View Subject | View Object

The cell cycle protein p21, encoded by Cdkn1a, is upregulated in many senescent cell types and has been associated with DNA damage during neuronal aging (Jurk et al., 2012) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease

p(MGI:Mapt, var("p.Pro301Leu")) increases p(MGI:Cdkn1a) View Subject | View Object

TauNFT brains expressed 3-fold higher Cdkn1a than control mice (P = 0.0178, Figure 1f), which was replicated in a separate mouse cohort (P = 0.0086, Figure S1f) PubMed:30126037

Appears in Networks:
Annotations
Confidence
High
MeSH
Neurons
MeSH
Alzheimer Disease

Out-Edges 0

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.