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p(HGNC:SET)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
SET
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer v1.0.0

Protein phosphatase 2A dysfunction in Alzheimer’s disease v1.0.0

PP2A and Alzheimer Disease v1.0.0

In-Edges 8

path(MESH:"Alzheimer Disease") increases p(HGNC:SET) View Subject | View Object

In Alzheimer's disease, inhibition of PP2A activity by SET leads to hyper phosphorylation of the Tau protein [47]. PubMed:23454242

Appears in Networks:

act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) View Subject | View Object

Up-regulation of I1 PP2A and I2 PP2A, and mislocalization and cleavage of I2 PP2A, could underlie the inactivation of PP2A in AD neocortical neurons (Tanimukai et al.,2005). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Alzheimer Disease

act(complex(GO:"protein phosphatase type 2A complex")) negativeCorrelation p(HGNC:SET) View Subject | View Object

For instance, activated GSK3β has been reported to induce PP2A inactivation via several mechanisms: phosphorylation of PP2A on Tyr307 (Yao et al.,2011); demethylation of PP2A on Leu309 through inhibition of LCMT1 and up-regulation of PME1 (Yao et al.,2012); and accumulation of I2 PP2A (Liu et al.,2008a). PubMed:24653673

Appears in Networks:

complex(p(HGNC:PPP2CA), p(HGNC:SET)) hasComponent p(HGNC:SET) View Subject | View Object

Appears in Networks:

act(p(HGNC:GSK3B)) increases p(HGNC:SET) View Subject | View Object

For instance, activated GSK3β has been reported to induce PP2A inactivation via several mechanisms: phosphorylation of PP2A on Tyr307 (Yao et al.,2011); demethylation of PP2A on Leu309 through inhibition of LCMT1 and up-regulation of PME1 (Yao et al.,2012); and accumulation of I2 PP2A (Liu et al.,2008a). PubMed:24653673

Appears in Networks:

complex(p(HGNC:PPP2CB), p(HGNC:SET)) hasComponent p(HGNC:SET) View Subject | View Object

Appears in Networks:

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) View Subject | View Object

Up-regulation of I1 PP2A and I2 PP2A, and mislocalization and cleavage of I2 PP2A, could underlie the inactivation of PP2A in AD neocortical neurons (Tanimukai et al.,2005). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Alzheimer Disease

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:SET) View Subject | View Object

Complementing these findings, immu- nohistochemical and western blot studies have shown re- duced expression of PPMT [77], and up-regulation of the PP2A inhibitors I 1 and I 2 in AD cases [79, 80]. PubMed:22299660

Appears in Networks:

Out-Edges 10

p(HGNC:SET) decreases act(p(FPLX:PPP2)) View Subject | View Object

The phosphoprotein SET is a potent inhibitor of PP2A activity [45]. PubMed:23454242

Appears in Networks:

p(HGNC:SET) hasVariant p(HGNC:SET, frag("?")) View Subject | View Object

Appears in Networks:

p(HGNC:SET) decreases act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

Natural toxins such as okadaic acid, calyculin ,and fostriecin (Reviewed in Swingle et al., 2007), and endogenous nuclear inhibitors called I1 PP2A and I2 PP2A/SET (Li and Damuni, 1998), can directly bind to the catalytic subunit and inhibit the phosphatase activity of the entire family of PP2A enzymes. PubMed:24653673

Appears in Networks:

p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

Up-regulation of I1 PP2A and I2 PP2A, and mislocalization and cleavage of I2 PP2A, could underlie the inactivation of PP2A in AD neocortical neurons (Tanimukai et al.,2005). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Alzheimer Disease

p(HGNC:SET) negativeCorrelation act(complex(GO:"protein phosphatase type 2A complex")) View Subject | View Object

For instance, activated GSK3β has been reported to induce PP2A inactivation via several mechanisms: phosphorylation of PP2A on Tyr307 (Yao et al.,2011); demethylation of PP2A on Leu309 through inhibition of LCMT1 and up-regulation of PME1 (Yao et al.,2012); and accumulation of I2 PP2A (Liu et al.,2008a). PubMed:24653673

Appears in Networks:

p(HGNC:SET) increases complex(p(HGNC:PPP2CA), p(HGNC:SET)) View Subject | View Object

Natural toxins such as okadaic acid, calyculin ,and fostriecin (Reviewed in Swingle et al., 2007), and endogenous nuclear inhibitors called I1 PP2A and I2 PP2A/SET (Li and Damuni, 1998), can directly bind to the catalytic subunit and inhibit the phosphatase activity of the entire family of PP2A enzymes. PubMed:24653673

Appears in Networks:

p(HGNC:SET) increases complex(p(HGNC:PPP2CB), p(HGNC:SET)) View Subject | View Object

Natural toxins such as okadaic acid, calyculin ,and fostriecin (Reviewed in Swingle et al., 2007), and endogenous nuclear inhibitors called I1 PP2A and I2 PP2A/SET (Li and Damuni, 1998), can directly bind to the catalytic subunit and inhibit the phosphatase activity of the entire family of PP2A enzymes. PubMed:24653673

Appears in Networks:

p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Up-regulation of I1 PP2A and I2 PP2A, and mislocalization and cleavage of I2 PP2A, could underlie the inactivation of PP2A in AD neocortical neurons (Tanimukai et al.,2005). PubMed:24653673

Appears in Networks:
Annotations
MeSH
Neocortex
MeSH
Alzheimer Disease

p(HGNC:SET) decreases act(p(FPLX:PPP2)) View Subject | View Object

Complementing these findings, immu- nohistochemical and western blot studies have shown re- duced expression of PPMT [77], and up-regulation of the PP2A inhibitors I 1 and I 2 in AD cases [79, 80]. PubMed:22299660

Appears in Networks:

p(HGNC:SET) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

Complementing these findings, immu- nohistochemical and western blot studies have shown re- duced expression of PPMT [77], and up-regulation of the PP2A inhibitors I 1 and I 2 in AD cases [79, 80]. PubMed:22299660

Appears in Networks:

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.