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Neocortex

Name
Neocortex
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

a(MESH:"Cholinergic Neurons") increases act(p(HGNC:CHAT)) View Subject | View Object

Loss of cholinergic neurons has often been demonstrated as lowered ChAT activity in brains of patients with AD. Early post mortem studies indicated a loss of ChAT activity restricted to the neocortex (Slotkin et al., 1990) and this has been confirmed in more recent studies on frontal lobe and temporal cortex (Lai et al., 2006). It is noteworthy that an increase in ChAT activity in the surviving neurons was interpreted as a possible compensatory mechanism (Slotkin et al., 1990). PubMed:19293145

Appears in Networks:
Annotations
MeSH
Frontal Lobe
MeSH
Neocortex
MeSH
Temporal Lobe

path(MESH:"Alzheimer Disease") decreases a(MESH:"Cholinergic Neurons") View Subject | View Object

Loss of cholinergic neurons has often been demonstrated as lowered ChAT activity in brains of patients with AD. Early post mortem studies indicated a loss of ChAT activity restricted to the neocortex (Slotkin et al., 1990) and this has been confirmed in more recent studies on frontal lobe and temporal cortex (Lai et al., 2006). It is noteworthy that an increase in ChAT activity in the surviving neurons was interpreted as a possible compensatory mechanism (Slotkin et al., 1990). PubMed:19293145

Appears in Networks:
Annotations
MeSH
Frontal Lobe
MeSH
Neocortex
MeSH
Temporal Lobe

path(MESH:"Alzheimer Disease") increases bp(GO:"neuron death") View Subject | View Object

AD also involves loss of neurons, beginning in the entorhinal cortex and later spreading to the neocortex (Braak et al., 2006); early in the disease, nicotinic acetylcholine receptors (nAChRs) are lost (Kadir et al., 2006). PubMed:19293145

Appears in Networks:
Annotations
MeSH
Entorhinal Cortex
MeSH
Neocortex

bp(GO:"regulation of action potential firing pattern") association p(FPLX:CHRN) View Subject | View Object

Acting through these excitatory and inhibitory inputs and nAChRs located on the DA neurons, nicotinic receptors influence the firing modes and firing frequency of DA neurons (119, 121). PubMed:17009926

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron
MeSH
Dendrites
MeSH
Neocortex

bp(GO:"regulation of action potential firing rate") association p(FPLX:CHRN) View Subject | View Object

Acting through these excitatory and inhibitory inputs and nAChRs located on the DA neurons, nicotinic receptors influence the firing modes and firing frequency of DA neurons (119, 121). PubMed:17009926

Appears in Networks:
Annotations
Cell Ontology (CL)
midbrain dopaminergic neuron
MeSH
Dendrites
MeSH
Neocortex

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.