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bp(MESH:"Heat-Shock Response")

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Entity

Name
Heat-Shock Response
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 3

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Corticotropin-releasing factor regulates caspase-3 and may protect developing zebrafish from stress-induced apoptosis v1.0.0

Molecular Chaperone Functions in Protein Folding and Proteostasis v1.0.0

In-Edges 3

a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response") View Subject | View Object

However, embryos that recovered from heat shock in the presence of the CRF-R1 antagonist, antalarmin, experienced a greater increase in caspase-3 activity than embryos not given the antagonist PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

act(p(NCBIGENE:140621)) association bp(MESH:"Heat-Shock Response") View Subject | View Object

The endogenous response to heat shock was characterized by transient changes in caspase-3 activity and gene expression. PubMed:29807032

Appears in Networks:

p(FPLX:HSP90) association bp(MESH:"Heat-Shock Response") View Subject | View Object

Accordingly, Hsp90 affects many key cellular processes, including cell cycle progression, steroid signaling, calcium signaling, protein trafficking, protein secretion, the immune re- sponse, and the heat shock response (HSR) (45, 48, 82). PubMed:23746257

Appears in Networks:

Out-Edges 12

bp(MESH:"Heat-Shock Response") increases bp(GO:"response to unfolded protein") View Subject | View Object

Overexpression of Parkin can rescue cells from the UPR elicited by a variety of stresses, such as exposure to H2O2, DNA alkylating agents, short-wavelength UV light, high osmolarity, and heat shock (Imai et al., 2000) PubMed:14556719

Appears in Networks:

bp(MESH:"Heat-Shock Response") association act(p(NCBIGENE:140621)) View Subject | View Object

The endogenous response to heat shock was characterized by transient changes in caspase-3 activity and gene expression. PubMed:29807032

Appears in Networks:

bp(MESH:"Heat-Shock Response") increases act(p(NCBIGENE:140621)) View Subject | View Object

For embryos heat shocked at 6 hpf, the induction of caspase-3 activity was dependent on recovery time (interaction of main variables P=0.007), with a significant increase over controls at 7 h and 10 h recovery (Table 1). PubMed:29807032

Appears in Networks:

bp(MESH:"Heat-Shock Response") increases p(NCBIGENE:492507) View Subject | View Object

In embryos heat shocked at 6 hpf, crf abundance increased relative to controls after 4 h recovery, but there were no differences at 7 h or 10 h recovery (Fig. 1A). PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

bp(MESH:"Heat-Shock Response") causesNoChange p(NCBIGENE:492507) View Subject | View Object

In embryos heat shocked at 6 hpf, crf abundance increased relative to controls after 4 h recovery, but there were no differences at 7 h or 10 h recovery (Fig. 1A). PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

bp(MESH:"Heat-Shock Response") increases p(MESH:"corticotropin releasing factor-binding protein") View Subject | View Object

The endogenous response to heat shock was also characterized by an increase in crf-bp mRNA levels independent of recovery time (main effect of heat shock P<0.05), and this was true for embryos exposed to the stressor at 6 hpf (Fig. 1C) and at 30 hpf (Fig. 1D). PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") View Subject | View Object

Heat shock significantly increased embryo mortality relative to non-heat shocked embryos PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") View Subject | View Object

Final cumulative mortality (at 10 h recovery) in non-heat shocked embryos was low in both the 0 nM and 10 nM antalarmin groups (4.7% and 8.3%, respectively), and heat shock increased mortality in both groups PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") View Subject | View Object

The greatest heat shock-induced mortality occurred during the first 1 h of recovery and plateaued after 5 h recovery (main effect of time P<0.001; n=3; Fig. 3B), but the presence of antalarmin did not influence this response. PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

bp(MESH:"Heat-Shock Response") increases a(MESH:"Heat-Shock Proteins") View Subject | View Object

Many are stress proteins or heat shock proteins (Hsps), as their synthesis is induced under conditions of stress (e.g., heat shock or oxidative stress), which structurally destabilize a subset of cellular proteins. PubMed:23746257

Appears in Networks:

bp(MESH:"Heat-Shock Response") association p(FPLX:HSP90) View Subject | View Object

Accordingly, Hsp90 affects many key cellular processes, including cell cycle progression, steroid signaling, calcium signaling, protein trafficking, protein secretion, the immune re- sponse, and the heat shock response (HSR) (45, 48, 82). PubMed:23746257

Appears in Networks:

bp(MESH:"Heat-Shock Response") regulates bp(HBP:Proteostasis) View Subject | View Object

The PN is regulated by interconnected pathways that respond to specific forms of cellular stress, including the cytosolic heat shock response (HSR) (191), the unfolded protein response (UPR) in the endoplas- mic reticulum (192), and the mitochondrial UPR (193). PubMed:23746257

Appears in Networks:
Annotations
MeSH
Cytosol

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.