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  4. embryonic cell line

embryonic cell line

Name
embryonic cell line
Namespace Keyword
CellLine
Namespace
Experimental Factor Ontology (EFO)
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/cell-line/cell-line-20170511.belanno

Sample Annotated Edges 5

bp(MESH:"Heat-Shock Response") decreases a(MESH:"Embryonic Structures") View Subject | View Object

Final cumulative mortality (at 10 h recovery) in non-heat shocked embryos was low in both the 0 nM and 10 nM antalarmin groups (4.7% and 8.3%, respectively), and heat shock increased mortality in both groups PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

p(NCBIGENE:492507) decreases act(p(NCBIGENE:140621)) View Subject | View Object

CRF overexpression by mRNA microinjection reduced heat shock-induced caspase-3 activity by approximately 2-fold relative to control-injected embryos PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

a(MESH:antalarmin) causesNoChange a(MESH:"Embryonic Structures") View Subject | View Object

The greatest heat shock-induced mortality occurred during the first 1 h of recovery and plateaued after 5 h recovery (main effect of time P<0.001; n=3; Fig. 3B), but the presence of antalarmin did not influence this response. PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

a(MESH:antalarmin) decreases bp(MESH:"Heat-Shock Response") View Subject | View Object

However, embryos that recovered from heat shock in the presence of the CRF-R1 antagonist, antalarmin, experienced a greater increase in caspase-3 activity than embryos not given the antagonist PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

bp(MESH:"Heat-Shock Response") causesNoChange p(NCBIGENE:492507) View Subject | View Object

In embryos heat shocked at 6 hpf, crf abundance increased relative to controls after 4 h recovery, but there were no differences at 7 h or 10 h recovery (Fig. 1A). PubMed:29807032

Appears in Networks:
Annotations
Experimental Factor Ontology (EFO)
embryonic cell line

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.