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bp(GO:"response to unfolded protein")

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Entity

Name
response to unfolded protein
Namespace
go
Namespace Version
20180921
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Appears in Networks 2

The Ubiquitin Proteasome System in Neurodegenerative Diseases: Sometimes the Chicken, Sometimes the Egg v1.0.0

Molecular Chaperone Functions in Protein Folding and Proteostasis v1.0.0

In-Edges 8

a(CHEBI:"alkylating agent") increases bp(GO:"response to unfolded protein") View Subject | View Object

Overexpression of Parkin can rescue cells from the UPR elicited by a variety of stresses, such as exposure to H2O2, DNA alkylating agents, short-wavelength UV light, high osmolarity, and heat shock (Imai et al., 2000) PubMed:14556719

Appears in Networks:

a(CHEBI:"hydrogen peroxide") increases bp(GO:"response to unfolded protein") View Subject | View Object

Overexpression of Parkin can rescue cells from the UPR elicited by a variety of stresses, such as exposure to H2O2, DNA alkylating agents, short-wavelength UV light, high osmolarity, and heat shock (Imai et al., 2000) PubMed:14556719

Appears in Networks:

bp(MESH:"Heat-Shock Response") increases bp(GO:"response to unfolded protein") View Subject | View Object

Overexpression of Parkin can rescue cells from the UPR elicited by a variety of stresses, such as exposure to H2O2, DNA alkylating agents, short-wavelength UV light, high osmolarity, and heat shock (Imai et al., 2000) PubMed:14556719

Appears in Networks:

bp(MESH:"Osmolar Concentration") positiveCorrelation bp(GO:"response to unfolded protein") View Subject | View Object

Overexpression of Parkin can rescue cells from the UPR elicited by a variety of stresses, such as exposure to H2O2, DNA alkylating agents, short-wavelength UV light, high osmolarity, and heat shock (Imai et al., 2000) PubMed:14556719

Appears in Networks:

bp(MESH:"Ultraviolet Rays") increases bp(GO:"response to unfolded protein") View Subject | View Object

Overexpression of Parkin can rescue cells from the UPR elicited by a variety of stresses, such as exposure to H2O2, DNA alkylating agents, short-wavelength UV light, high osmolarity, and heat shock (Imai et al., 2000) PubMed:14556719

Appears in Networks:

p(HGNC:PRKN) decreases bp(GO:"response to unfolded protein") View Subject | View Object

Overexpression of Parkin can rescue cells from the UPR elicited by a variety of stresses, such as exposure to H2O2, DNA alkylating agents, short-wavelength UV light, high osmolarity, and heat shock (Imai et al., 2000) PubMed:14556719

Appears in Networks:

p(MESH:Proteins, pmod(HBP:misfolding)) increases bp(GO:"response to unfolded protein") View Subject | View Object

The UPR is a mechanism that involves a stress response in the ER, including increased biosynthesis of ER chaperones, in response to accumulation of misfolded/denatured/mutated proteins in this organelle (for a recent review on UPR, see Kaufman, 2002). PubMed:14556719

Appears in Networks:
Annotations
MeSH
Endoplasmic Reticulum

p(MESH:Proteins, var("?")) increases bp(GO:"response to unfolded protein") View Subject | View Object

The UPR is a mechanism that involves a stress response in the ER, including increased biosynthesis of ER chaperones, in response to accumulation of misfolded/denatured/mutated proteins in this organelle (for a recent review on UPR, see Kaufman, 2002). PubMed:14556719

Appears in Networks:
Annotations
MeSH
Endoplasmic Reticulum

Out-Edges 5

bp(GO:"response to unfolded protein") increases bp(GO:"cell death") View Subject | View Object

It then aggregates, and the insoluble protein elicits cell death via the Unfolded Protein Response (UPR). PubMed:14556719

Appears in Networks:

bp(GO:"response to unfolded protein") increases bp(GO:"response to endoplasmic reticulum stress") View Subject | View Object

The UPR is a mechanism that involves a stress response in the ER, including increased biosynthesis of ER chaperones, in response to accumulation of misfolded/denatured/mutated proteins in this organelle (for a recent review on UPR, see Kaufman, 2002). PubMed:14556719

Appears in Networks:
Annotations
MeSH
Endoplasmic Reticulum

bp(GO:"response to unfolded protein") increases a(MESH:"Molecular Chaperones") View Subject | View Object

The UPR is a mechanism that involves a stress response in the ER, including increased biosynthesis of ER chaperones, in response to accumulation of misfolded/denatured/mutated proteins in this organelle (for a recent review on UPR, see Kaufman, 2002). PubMed:14556719

Appears in Networks:
Annotations
MeSH
Endoplasmic Reticulum

bp(GO:"response to unfolded protein") positiveCorrelation bp(MESH:"Osmolar Concentration") View Subject | View Object

Overexpression of Parkin can rescue cells from the UPR elicited by a variety of stresses, such as exposure to H2O2, DNA alkylating agents, short-wavelength UV light, high osmolarity, and heat shock (Imai et al., 2000) PubMed:14556719

Appears in Networks:

bp(GO:"response to unfolded protein") regulates bp(HBP:Proteostasis) View Subject | View Object

The PN is regulated by interconnected pathways that respond to specific forms of cellular stress, including the cytosolic heat shock response (HSR) (191), the unfolded protein response (UPR) in the endoplas- mic reticulum (192), and the mitochondrial UPR (193). PubMed:23746257

Appears in Networks:
Annotations
MeSH
Endoplasmic Reticulum
MeSH
Mitochondria

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.