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a(MESH:"Heat-Shock Proteins")

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Entity

Name
Heat-Shock Proteins
Namespace
MeSH
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/01c9daa61012b37dd0a1bc962521ba51a15b38f1/external/mesh-names.belns

Appears in Networks 3

Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies v1.0.0

Molecular Chaperone Functions in Protein Folding and Proteostasis v1.0.0

Molecular chaperones and proteostasis regulation during redox imbalance v1.0.0

In-Edges 6

bp(GO:"cellular response to stress") increases a(MESH:"Heat-Shock Proteins") View Subject | View Object

Several members of the chaperone family are upregulated in response to stress and, thus, these factors have been termed heat shock proteins (Hsps) PubMed:21882945

Appears in Networks:

p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") View Subject | View Object

The expression of Hsps is regulated by heat shock factor 1 (HSF1), which, under stress conditions, becomes associated with heat shock elements to elevate the transcription of Hsps and other proteins [51]. PubMed:21882945

Appears in Networks:

bp(GO:"response to oxidative stress") increases a(MESH:"Heat-Shock Proteins") View Subject | View Object

Many are stress proteins or heat shock proteins (Hsps), as their synthesis is induced under conditions of stress (e.g., heat shock or oxidative stress), which structurally destabilize a subset of cellular proteins. PubMed:23746257

Appears in Networks:

bp(MESH:"Heat-Shock Response") increases a(MESH:"Heat-Shock Proteins") View Subject | View Object

Many are stress proteins or heat shock proteins (Hsps), as their synthesis is induced under conditions of stress (e.g., heat shock or oxidative stress), which structurally destabilize a subset of cellular proteins. PubMed:23746257

Appears in Networks:

bp(MESH:"Stress, Physiological") increases a(MESH:"Heat-Shock Proteins") View Subject | View Object

Many are stress proteins or heat shock proteins (Hsps), as their synthesis is induced under conditions of stress (e.g., heat shock or oxidative stress), which structurally destabilize a subset of cellular proteins. PubMed:23746257

Appears in Networks:

p(HGNC:HSF1) increases a(MESH:"Heat-Shock Proteins") View Subject | View Object

HSF1 binds to a consensus heat shock element (HSE) within the promoter regions of HSP genes resulting in the activation of HSPs' gene expression and the control of cellular responses to oxidative and proteotoxic stress [108]. PubMed:24563850

Appears in Networks:

Out-Edges 3

a(MESH:"Heat-Shock Proteins") increases bp(GO:"proteasomal protein catabolic process") View Subject | View Object

Importantly, the Hsps are also critical at the end of a protein’s life, as they facilitate turnover by the proteasome system and the clearance of proteotoxic aggregates by autophagy [53] PubMed:21882945

Appears in Networks:

a(MESH:"Heat-Shock Proteins") increases bp(GO:autophagy) View Subject | View Object

Importantly, the Hsps are also critical at the end of a protein’s life, as they facilitate turnover by the proteasome system and the clearance of proteotoxic aggregates by autophagy [53] PubMed:21882945

Appears in Networks:

a(MESH:"Heat-Shock Proteins") regulates bp(GO:"response to oxidative stress") View Subject | View Object

HSF1 binds to a consensus heat shock element (HSE) within the promoter regions of HSP genes resulting in the activation of HSPs' gene expression and the control of cellular responses to oxidative and proteotoxic stress [108]. PubMed:24563850

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.