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p(HGNC:CCL2)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CCL2
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 3

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Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 3

a(PUBCHEM:11249342) decreases p(HGNC:CCL2) View Subject | View Object

A significant lowering of pro-inflammatory, C3 (86.9%) and microglial activation markers, MCP-1 (87.5%) and YKL-40 (72.7%), was evident. PubMed:22791904

Appears in Networks:

a(HBP:HBP00038) increases p(HGNC:CCL2) View Subject | View Object

The deposition of fibrillar Ab in the AD brain results in the recruitment of microglia to the plaques owing to their expression of CCL2, which acts to attract microglia [82]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

a(HBP:HBP00089) increases sec(p(HGNC:CCL2)) View Subject | View Object

The plaque-associated microglia secrete a variety of cytotoxic species including the inflammatory cytokines, INF-g, TNF-a, IL-1b and IL-6 and chemokines, most prominently CCL2 [10-12]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

Out-Edges 3

p(HGNC:CCL2) increases bp(GO:"microglial cell activation") View Subject | View Object

The deposition of fibrillar Ab in the AD brain results in the recruitment of microglia to the plaques owing to their expression of CCL2, which acts to attract microglia [82]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
Medium

p(HGNC:CCL2) increases path(MESH:Inflammation) View Subject | View Object

Pro-inflammatory cytokines and chemokines [e.g., inter leukin 1B (IL1B), CXCL8 (also termed IL8), TNF and chemokine (C-C motif) ligand 2 (CCL2, also termed MCP1)], are upregulated in haemolytic disorders such as SCD (Qari et al, 2012). This pro-inflammatory cytokine milieu is crucial in mediating the pro-coagulant effects of vascular endothelial cells and promotes localized inflammation and thrombosis (Qari et al, 2012). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

p(HGNC:CCL2) increases path(MESH:Thrombosis) View Subject | View Object

Pro-inflammatory cytokines and chemokines [e.g., inter leukin 1B (IL1B), CXCL8 (also termed IL8), TNF and chemokine (C-C motif) ligand 2 (CCL2, also termed MCP1)], are upregulated in haemolytic disorders such as SCD (Qari et al, 2012). This pro-inflammatory cytokine milieu is crucial in mediating the pro-coagulant effects of vascular endothelial cells and promotes localized inflammation and thrombosis (Qari et al, 2012). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
endothelial cell
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Hemolytic, Autoimmune
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.