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a(HBP:HBP00089)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
HBP00089
Namespace
HBP
Namespace Version
20181029
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/785431732a26d6809b4162d98b95687d16404e63/export/hbp.belns

Appears in Networks 1

Nuclear receptors as therapeutic targets for Alzheimer's disease. v1.0.0

In-Edges 2

bp(GO:"microglial cell activation") association a(HBP:HBP00089) View Subject | View Object

The development of dense-core amyloid plaques is associated with a robust immune response mediated by microglial cells. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

bp(GO:"microglial cell activation") positiveCorrelation a(HBP:HBP00089) View Subject | View Object

The appearance of amyloid deposition in the AD brain coincides with a dramatic phenotypic activation of microglial cells in the surrounding area. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

Out-Edges 7

a(HBP:HBP00089) association bp(GO:"microglial cell activation") View Subject | View Object

The development of dense-core amyloid plaques is associated with a robust immune response mediated by microglial cells. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

a(HBP:HBP00089) positiveCorrelation bp(GO:"microglial cell activation") View Subject | View Object

The appearance of amyloid deposition in the AD brain coincides with a dramatic phenotypic activation of microglial cells in the surrounding area. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

a(HBP:HBP00089) increases sec(p(HGNC:IFNG)) View Subject | View Object

The plaque-associated microglia secrete a variety of cytotoxic species including the inflammatory cytokines, INF-g, TNF-a, IL-1b and IL-6 and chemokines, most prominently CCL2 [10-12]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

a(HBP:HBP00089) increases sec(p(HGNC:TNF)) View Subject | View Object

The plaque-associated microglia secrete a variety of cytotoxic species including the inflammatory cytokines, INF-g, TNF-a, IL-1b and IL-6 and chemokines, most prominently CCL2 [10-12]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

a(HBP:HBP00089) increases sec(p(HGNC:IL1B)) View Subject | View Object

The plaque-associated microglia secrete a variety of cytotoxic species including the inflammatory cytokines, INF-g, TNF-a, IL-1b and IL-6 and chemokines, most prominently CCL2 [10-12]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

a(HBP:HBP00089) increases sec(p(HGNC:IL6)) View Subject | View Object

The plaque-associated microglia secrete a variety of cytotoxic species including the inflammatory cytokines, INF-g, TNF-a, IL-1b and IL-6 and chemokines, most prominently CCL2 [10-12]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

a(HBP:HBP00089) increases sec(p(HGNC:CCL2)) View Subject | View Object

The plaque-associated microglia secrete a variety of cytotoxic species including the inflammatory cytokines, INF-g, TNF-a, IL-1b and IL-6 and chemokines, most prominently CCL2 [10-12]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High
MeSH
Microglia

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.