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p(MGI:Aqp4)

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Entity

Name
Aqp4
Namespace
MGI
Namespace Version
20170725
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/mgi-mouse-genes/mgi-mouse-genes-20170725.belns

Appears in Networks 2

Functional aspects of meningeal lymphatics in ageing and Alzheimer’s disease v1.0.0

Clearance systems in the brain-implications for Alzheimer disease. v1.0.1

In-Edges 0

Out-Edges 5

p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(GO:"extracellular space"), toLoc(MESH:"Intracellular Space")) View Subject | View Object

Within the brain parenchyma, it was shown that aquaporin 4 (AQP4) expression by astrocytes plays an important role in the modulation of paravascular CSF macromolecule influx and efflux (through the glymphatic route) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Parenchymal Tissue

p(MGI:Aqp4) regulates tloc(a(CHEBI:macromolecule), fromLoc(MESH:"Intracellular Space"), toLoc(GO:"extracellular space")) View Subject | View Object

Within the brain parenchyma, it was shown that aquaporin 4 (AQP4) expression by astrocytes plays an important role in the modulation of paravascular CSF macromolecule influx and efflux (through the glymphatic route) PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Brain
MeSH
Cerebrospinal Fluid
MeSH
Parenchymal Tissue

p(MGI:Aqp4) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

Deletion of Aqp4 in transgenic mice with Alzheimer’s disease also resulted in increased amyloid-β plaque burden and exacerbated cognitive impairment PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease

p(MGI:Aqp4) increases bp(GO:cognition) View Subject | View Object

Deletion of Aqp4 in transgenic mice with Alzheimer’s disease also resulted in increased amyloid-β plaque burden and exacerbated cognitive impairment PubMed:30046111

Appears in Networks:
Annotations
Confidence
High
MeSH
Alzheimer Disease

act(p(MGI:Aqp4)) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

Recent mouse studies suggest that the AQP4-dependent glymphatic pathway is an important clearance system for driving the removal of soluble Aβ from the interstitium. PubMed:26195256

Appears in Networks:
Annotations
MeSH
Hippocampus
MeSH
Temporal Lobe

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.