1. Catalog
  2. Namespaces
  3. MeSH
  4. Temporal Lobe

Temporal Lobe

Name
Temporal Lobe
Namespace Keyword
MeSHAnatomy
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-anatomy/mesh-anatomy-20170511.belanno

Sample Annotated Edges 5

act(p(HGNC:ADAM10)) negativeCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

A dramatically reduced ADAM10 protein level in the platelets of sporadic AD patients was also found to correlate with the significantly decreased sAPPalpha levels found in their platlets and cerebrospinal fluid [55] and the reduced alpha-secretase activity in the temporal cortex homogenates of AD patients [56] PubMed:21214928

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Temporal Lobe

a(HBP:HBP00067) regulates bp(GO:"central nervous system formation") View Subject | View Object

In contrast to Abeta, sAPPalpha has an important role in neuronal plasticity/survival and is protective against excitotoxicity [42,43]. sAPPalpha also regulates neural stem cell proliferation and is important for early CNS development [57,58] PubMed:21214928

Appears in Networks:
Annotations
Confidence
High
MeSH
Temporal Lobe

bp(GO:"regulation of neuronal synaptic plasticity") association a(HBP:HBP00067) View Subject | View Object

In contrast to Abeta, sAPPalpha has an important role in neuronal plasticity/survival and is protective against excitotoxicity [42,43]. sAPPalpha also regulates neural stem cell proliferation and is important for early CNS development [57,58] PubMed:21214928

Appears in Networks:
Annotations
Confidence
High
MeSH
Temporal Lobe

path(MESH:"Alzheimer Disease") negativeCorrelation act(p(HGNC:ADAM10)) View Subject | View Object

A dramatically reduced ADAM10 protein level in the platelets of sporadic AD patients was also found to correlate with the significantly decreased sAPPalpha levels found in their platlets and cerebrospinal fluid [55] and the reduced alpha-secretase activity in the temporal cortex homogenates of AD patients [56] PubMed:21214928

Appears in Networks:
Annotations
Confidence
Medium
MeSH
Temporal Lobe

a(HBP:HBP00067) association bp(GO:"regulation of neuronal synaptic plasticity") View Subject | View Object

In contrast to Abeta, sAPPalpha has an important role in neuronal plasticity/survival and is protective against excitotoxicity [42,43]. sAPPalpha also regulates neural stem cell proliferation and is important for early CNS development [57,58] PubMed:21214928

Appears in Networks:
Annotations
Confidence
High
MeSH
Temporal Lobe

Showing 5 of 68 edges

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.