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r(HGNC:CHI3L1)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
CHI3L1
Namespace
hgnc
Namespace Version
20180828
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/1b20f0637c395f8aa89c2e2e342d7b704062c242/external/hgnc-symbols.belns

Appears in Networks 2

Nuclear receptors as therapeutic targets for Alzheimer's disease. v1.0.0

RelB/p50 complexes regulate cytokine-induced YKL-40 expression v1.0.0

In-Edges 3

path(MESH:"Alzheimer Disease") positiveCorrelation r(HGNC:CHI3L1) View Subject | View Object

In this study, it was shown that samples from human AD brains as well as two aged mouse models of AD showed increased mRNA levels of the M2 markers, Arg1 and Ym1, when compared to age matched controls [101]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

p(HGNC:IL1A) causesNoChange r(HGNC:CHI3L1) View Subject | View Object

In contrast to astrocytes and U373 cells, we found that basal expression of YKL-40 and RelB mRNA was very high in primary human chondrocytes and not stimulated by IL-1 or OSM (Supplementary Fig 3). PubMed:25681350

Appears in Networks:
Annotations
Cell Ontology (CL)
chondrocyte

p(HGNC:OSM) causesNoChange r(HGNC:CHI3L1) View Subject | View Object

In contrast to astrocytes and U373 cells, we found that basal expression of YKL-40 and RelB mRNA was very high in primary human chondrocytes and not stimulated by IL-1 or OSM (Supplementary Fig 3). PubMed:25681350

Appears in Networks:
Annotations
Cell Ontology (CL)
chondrocyte

Out-Edges 1

r(HGNC:CHI3L1) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

In this study, it was shown that samples from human AD brains as well as two aged mouse models of AD showed increased mRNA levels of the M2 markers, Arg1 and Ym1, when compared to age matched controls [101]. PubMed:21718217

Appears in Networks:
Annotations
Confidence
High

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.