1. Catalog
  2. Nodes
  3. r(MGI:"chitinase-like 1")

r(MGI:"chitinase-like 1")

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
chitinase-like 1
Namespace
mgi
Namespace Version
20190224
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/c328ad964c08967a0417a887510b97b965a62fa5/external/mgi-names.belns

Appears in Networks 1

RelB/p50 complexes regulate cytokine-induced YKL-40 expression v1.0.0

In-Edges 9

a(PUBCHEM:14235) increases r(MGI:"chitinase-like 1") View Subject | View Object

Indeed, YKL-40 mRNA expression was robustly activated in tissues surrounding the site of turpentine injection and its induction was accompanied by a very strong induction of both IL-1 and IL-6 mRNAs (Fig. 1A) PubMed:25681350

Appears in Networks:

p(MGI:"avian reticuloendotheliosis viral (v-rel) oncogene related B") increases r(MGI:"chitinase-like 1") View Subject | View Object

Knockdown of either RelB or p50 significantly diminished cytokine-induced YKL-40 mRNA expression, whereas knockdown of p65, cRel and p52 had no effect (Fig. 4A). This finding implicates both RelB and p50 in YKL-40 regulation. PubMed:25681350

Appears in Networks:

p(MGI:"nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105") increases r(MGI:"chitinase-like 1") View Subject | View Object

Knockdown of either RelB or p50 significantly diminished cytokine-induced YKL-40 mRNA expression, whereas knockdown of p65, cRel and p52 had no effect (Fig. 4A). This finding implicates both RelB and p50 in YKL-40 regulation. PubMed:25681350

Appears in Networks:

p(MGI:"interleukin 1 alpha") increases r(MGI:"chitinase-like 1") View Subject | View Object

Downregulation of STAT3 (Fig. 3C) dramatically diminished IL-1/OSM-induced YKL-40 mRNA expression (Fig. 3A). PubMed:25681350

Appears in Networks:

p(MGI:"oncostatin M") increases r(MGI:"chitinase-like 1") View Subject | View Object

Downregulation of STAT3 (Fig. 3C) dramatically diminished IL-1/OSM-induced YKL-40 mRNA expression (Fig. 3A). PubMed:25681350

Appears in Networks:

p(MGI:"myelin oligodendrocyte glycoprotein", frag("35_50")) increases r(MGI:"chitinase-like 1") View Subject | View Object

Immunization of mice with MOG35-50 peptide resulted in the induction of EAE, and modest upregulation of YKL-40 mRNA expression in the spinal cords of animals (Fig. 1B). PubMed:25681350

Appears in Networks:
Annotations
MeSH
Spinal Cord

p(MGI:"signal transducer and activator of transcription 3") increases r(MGI:"chitinase-like 1") View Subject | View Object

Downregulation of STAT3 (Fig. 3C) dramatically diminished IL-1/OSM-induced YKL-40 mRNA expression (Fig. 3A). PubMed:25681350

Appears in Networks:

r(MGI:"interleukin 1 alpha") positiveCorrelation r(MGI:"chitinase-like 1") View Subject | View Object

Indeed, YKL-40 mRNA expression was robustly activated in tissues surrounding the site of turpentine injection and its induction was accompanied by a very strong induction of both IL-1 and IL-6 mRNAs (Fig. 1A) PubMed:25681350

Appears in Networks:

r(MGI:"interleukin 6") positiveCorrelation r(MGI:"chitinase-like 1") View Subject | View Object

Indeed, YKL-40 mRNA expression was robustly activated in tissues surrounding the site of turpentine injection and its induction was accompanied by a very strong induction of both IL-1 and IL-6 mRNAs (Fig. 1A) PubMed:25681350

Appears in Networks:

Out-Edges 2

r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 1 alpha") View Subject | View Object

Indeed, YKL-40 mRNA expression was robustly activated in tissues surrounding the site of turpentine injection and its induction was accompanied by a very strong induction of both IL-1 and IL-6 mRNAs (Fig. 1A) PubMed:25681350

Appears in Networks:

r(MGI:"chitinase-like 1") positiveCorrelation r(MGI:"interleukin 6") View Subject | View Object

Indeed, YKL-40 mRNA expression was robustly activated in tissues surrounding the site of turpentine injection and its induction was accompanied by a very strong induction of both IL-1 and IL-6 mRNAs (Fig. 1A) PubMed:25681350

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.