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path(HP:Hypercoagulability)

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Entity

Name
Hypercoagulability
Namespace
HP
Namespace Version
2017-10-05
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/namespace/hp/hp-20171108.belns

Appears in Networks 1

Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 4

a(CHEBI:"phosphatidyl-L-serine") positiveCorrelation path(HP:Hypercoagulability) View Subject | View Object

The abnormal phospholipid membrane asymmetry present in the RBCs of b-thalassaemia and SCD patients, with resultant phosphatidylserine exposure, appears to play a significant role in the aetiology of the observed hypercoagulable state and in the link between haemolysis and thrombosis (Ataga et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

a(MESH:"Cell-Derived Microparticles") increases path(HP:Hypercoagulability) View Subject | View Object

Irrespective of their source, elevated plasma levels of MPs are associated with a reduced clotting time and a dose- and time-dependent increase in thrombin generation, suggesting that the MPs enhance hypercoagulability. PubMed:28458720

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Veins
MeSH
beta-Thalassemia
Text Location
Review

p(HGNC:CD59, var("p.Cys89Tyr")) increases path(HP:Hypercoagulability) View Subject | View Object

Nonfunctioning CD59 is a major risk factor for stroke and hypercoagulability. PubMed:29929138

Appears in Networks:
Annotations
Text Location
Abstract

path(MESH:Thrombosis) positiveCorrelation path(HP:Hypercoagulability) View Subject | View Object

The triad consists of hypercoagulability, blood stasis and endothelial injury/dysfunction, which are useful concepts for understanding thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Text Location
Review

Out-Edges 2

path(HP:Hypercoagulability) positiveCorrelation path(MESH:Thrombosis) View Subject | View Object

The triad consists of hypercoagulability, blood stasis and endothelial injury/dysfunction, which are useful concepts for understanding thrombosis. PubMed:25307023

Appears in Networks:
Annotations
Text Location
Review

path(HP:Hypercoagulability) positiveCorrelation a(CHEBI:"phosphatidyl-L-serine") View Subject | View Object

The abnormal phospholipid membrane asymmetry present in the RBCs of b-thalassaemia and SCD patients, with resultant phosphatidylserine exposure, appears to play a significant role in the aetiology of the observed hypercoagulable state and in the link between haemolysis and thrombosis (Ataga et al, 2007). PubMed:25307023

Appears in Networks:
Annotations
Cell Ontology (CL)
erythrocyte
MeSH
Plasma
MeSH
Urine
MeSH
Anemia, Sickle Cell
MeSH
beta-Thalassemia
Text Location
Review

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.