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  4. Hypoxia

Hypoxia

Name
Hypoxia
Namespace Keyword
MeSHDisease
Namespace
MeSH
Namespace Version
20170511
Namespace URL
https://arty.scai.fraunhofer.de/artifactory/bel/annotation/mesh-diseases/mesh-diseases-20170511.belanno

Sample Annotated Edges 5

a(MESH:"Salivary Glands") increases rxn(reactants(a(CHEBI:nitrate)), products(a(CHEBI:nitrite))) View Subject | View Object

Studies have shown that nitrate concentrates in saliva and is reduced to nitrite by mouth commensal bacterial nitrate reductase and then nitrite is reduced to NO under acidic conditions of the stomach. 28,51,52 PubMed:27308950

Appears in Networks:
Annotations
MeSH
Saliva
MeSH
Hypoxia
Text Location
Discussion

a(MESH:Hemeproteins) increases rxn(reactants(a(CHEBI:nitrite)), products(a(CHEBI:"nitric oxide"))) View Subject | View Object

Several studies have shown that nitrite is reduced to NO by several heme proteins under hypoxic conditions, providing an eNOS-independent source of NO in the vasculature.28,47,48. PubMed:27308950

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hypoxia
Text Location
Discussion

a(MESH:Hemodilution) decreases a(CHEBI:nitrate) View Subject | View Object

The alternate explanation for a postoperative decrease in nitrate may be related to blood loss during and after surgery as well as hemodilution. PubMed:27308950

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hypoxia
Text Location
Discussion

p(HGNC:HBB) increases a(CHEBI:nitrate) View Subject | View Object

The cell-free Hb in stored RBCs should actually increase nitrate by oxidizing NO to nitrate. PubMed:27308950

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hypoxia
Text Location
Discussion

path(MESH:"Blood Loss, Surgical") decreases a(CHEBI:nitrate) View Subject | View Object

The alternate explanation for a postoperative decrease in nitrate may be related to blood loss during and after surgery as well as hemodilution. PubMed:27308950

Appears in Networks:
Annotations
MeSH
Plasma
MeSH
Hypoxia
Text Location
Discussion

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About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.