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Heme Curation v0.0.1-dev

Mechanistic knowledge surrounding heme

In-Edges 1

bp(MESH:"Blood Transfusion") decreases a(MESH:Hemodilution) View Subject | View Object

We calculated the loss of blood and extent of hemodilution during and after surgery based on the Hct levels for nontransfused patients (Table 1). Hct was significantly decreased (by approximately 20%, P = 0.0087) and hemodilution was significantly increased (P = 0.007) in these patients. PubMed:27308950

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Plasma
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Results

Out-Edges 5

a(MESH:Hemodilution) decreases a(CHEBI:nitrite) View Subject | View Object

Thus, we hypothesized that loss of blood during surgery and hemodilution from crystalloid administration might contribute to the observed decrease in plasma NOx levels. PubMed:27308950

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Plasma
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Results

a(MESH:Hemodilution) decreases a(CHEBI:nitrite) View Subject | View Object

Thus, it was apparent that blood loss and hemodilution from IV fluids rather than stored RBC transfusion likely played a role in the transient decrease of these NO metabolites. PubMed:27308950

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Plasma
Text Location
Discussion

a(MESH:Hemodilution) decreases a(CHEBI:nitrate) View Subject | View Object

Thus, we hypothesized that loss of blood during surgery and hemodilution from crystalloid administration might contribute to the observed decrease in plasma NOx levels. PubMed:27308950

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MeSH
Plasma
Text Location
Results

a(MESH:Hemodilution) decreases a(CHEBI:nitrate) View Subject | View Object

Thus, it was apparent that blood loss and hemodilution from IV fluids rather than stored RBC transfusion likely played a role in the transient decrease of these NO metabolites. PubMed:27308950

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Annotations
MeSH
Plasma
Text Location
Discussion

a(MESH:Hemodilution) decreases a(CHEBI:nitrate) View Subject | View Object

The alternate explanation for a postoperative decrease in nitrate may be related to blood loss during and after surgery as well as hemodilution. PubMed:27308950

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MeSH
Plasma
MeSH
Hypoxia
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Discussion

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.