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p(HGNC:MAPT, var("p.Glu391*"))

Equivalencies: 0 | Classes: 1 | Children: 0 | Explore

Entity

Name
MAPT
Namespace
hgnc
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/hgnc-names.belns

Appears in Networks 2

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies v1.0.0

Tau Modifications v1.9.5

Tau Modifications Sections of NESTOR

In-Edges 5

p(HBP:"paired helical filaments") association p(HGNC:MAPT, var("p.Glu391*")) View Subject | View Object

The tau fragment first isolated from the PHF core is approximately 100 amino acids in length. Its N-terminus was defined by sequence analysis [30,56], and its C-terminus was defined by epitope mapping of MN423. Immunoreactivity was shown to depend on a specific C-terminal trunctation at Glu391 [33,150]. PubMed:26751493

Appears in Networks:

p(HGNC:MAPT) hasVariant p(HGNC:MAPT, var("p.Glu391*")) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, pmod(Ph, Ser, 202)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) View Subject | View Object

E391-3610 mice (higher expressers) exhibit robust somatodendritic distribution of phospho- Ser 202/Thr 205 tau throughout the cortex, in hippocampal CA3 pyramidal neurons, CA1 apical dendrites and cell bodies and dentate granule cells. PubMed:22002427

Appears in Networks:
Annotations
Uberon
CA1 field of hippocampus
Uberon
CA3 field of hippocampus
Uberon
cerebral cortex
Uberon
dentate gyrus granule cell layer

p(HGNC:MAPT, pmod(Ph, Ser, 205)) positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) View Subject | View Object

E391-3610 mice (higher expressers) exhibit robust somatodendritic distribution of phospho- Ser 202/Thr 205 tau throughout the cortex, in hippocampal CA3 pyramidal neurons, CA1 apical dendrites and cell bodies and dentate granule cells. PubMed:22002427

Appears in Networks:
Annotations
Uberon
CA1 field of hippocampus
Uberon
CA3 field of hippocampus
Uberon
cerebral cortex
Uberon
dentate gyrus granule cell layer

path(MESH:"Alzheimer Disease") positiveCorrelation p(HGNC:MAPT, var("p.Glu391*")) View Subject | View Object

While several N and C-terminally truncated Tau species are observed in AD brains, only a limited number of specific Tau cleavage sites, after residues Asp13, Asp25, Asn368, Glu391 and Asp421, have been identified so far in situ. The species generated by these cleavages are found in neurofibrillary tangles, and their occurrence is correlated with the severity of the disease. PubMed:25974414

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

Out-Edges 7

p(HGNC:MAPT, var("p.Glu391*")) association p(HBP:"paired helical filaments") View Subject | View Object

The tau fragment first isolated from the PHF core is approximately 100 amino acids in length. Its N-terminus was defined by sequence analysis [30,56], and its C-terminus was defined by epitope mapping of MN423. Immunoreactivity was shown to depend on a specific C-terminal trunctation at Glu391 [33,150]. PubMed:26751493

Appears in Networks:

p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Glu391*")) partOf a(GO:"neurofibrillary tangle") View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation path(MESH:"Alzheimer Disease") View Subject | View Object

While several N and C-terminally truncated Tau species are observed in AD brains, only a limited number of specific Tau cleavage sites, after residues Asp13, Asp25, Asn368, Glu391 and Asp421, have been identified so far in situ. The species generated by these cleavages are found in neurofibrillary tangles, and their occurrence is correlated with the severity of the disease. PubMed:25974414

Appears in Networks:
Annotations
Disease Ontology (DO)
Alzheimer's disease

p(HGNC:MAPT, var("p.Glu391*")) isA p(HGNC:MAPT) View Subject | View Object

Appears in Networks:

p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 202)) View Subject | View Object

E391-3610 mice (higher expressers) exhibit robust somatodendritic distribution of phospho- Ser 202/Thr 205 tau throughout the cortex, in hippocampal CA3 pyramidal neurons, CA1 apical dendrites and cell bodies and dentate granule cells. PubMed:22002427

Appears in Networks:
Annotations
Uberon
CA1 field of hippocampus
Uberon
CA3 field of hippocampus
Uberon
cerebral cortex
Uberon
dentate gyrus granule cell layer

p(HGNC:MAPT, var("p.Glu391*")) positiveCorrelation p(HGNC:MAPT, pmod(Ph, Ser, 205)) View Subject | View Object

E391-3610 mice (higher expressers) exhibit robust somatodendritic distribution of phospho- Ser 202/Thr 205 tau throughout the cortex, in hippocampal CA3 pyramidal neurons, CA1 apical dendrites and cell bodies and dentate granule cells. PubMed:22002427

Appears in Networks:
Annotations
Uberon
CA1 field of hippocampus
Uberon
CA3 field of hippocampus
Uberon
cerebral cortex
Uberon
dentate gyrus granule cell layer

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.