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PubMed: 29238289

Title
Extracellular Tau and Its Potential Role in the Propagation of Tau Pathology.
Journal
Frontiers in neuroscience
Volume
11
Issue
None
Pages
667
Date
2017-01-01
Authors
Yamada K

Evidence 9a7de2bf7c
JSON

Rab7a (Rodriguez et al., 2017) and Rab1a (Mohamed et al., 2017) have been recently implicated in tau release, further suggesting that tau release involves vesicle transport.

a(MESH:"Transport Vesicles") association p(HGNC:MAPT) View Subject | View Object

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MeSH
Blood
MeSH
Cerebrospinal Fluid

p(HGNC:MAPT) association a(MESH:"Transport Vesicles") View Subject | View Object

Appears in Networks:
Annotations
MeSH
Blood
MeSH
Cerebrospinal Fluid

p(HGNC:MAPT) association p(HGNC:RAB7A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Blood
MeSH
Cerebrospinal Fluid

p(HGNC:MAPT) association p(HGNC:RAB1A) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Blood
MeSH
Cerebrospinal Fluid

p(HGNC:RAB1A) association p(HGNC:MAPT) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Blood
MeSH
Cerebrospinal Fluid

p(HGNC:RAB7A) association p(HGNC:MAPT) View Subject | View Object

Appears in Networks:
Annotations
MeSH
Blood
MeSH
Cerebrospinal Fluid

Evidence 571dfd4eb4
JSON

Tau from the CSF (Saman et al., 2012) and blood of patients with AD (Fiandaca et al., 2015) is associated with exosomes

act(a(MESH:Exosomes)) association p(HGNC:MAPT) View Subject | View Object

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MeSH
Blood
MeSH
Cerebrospinal Fluid

p(HGNC:MAPT) association act(a(MESH:Exosomes)) View Subject | View Object

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MeSH
Blood
MeSH
Cerebrospinal Fluid

Evidence d868fb38d9
JSON

starvation or lysosomal dysfunction increases tau release

act(a(MESH:Lysosomes)) decreases p(HGNC:MAPT) View Subject | View Object

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path(MESH:Starvation) increases p(HGNC:MAPT) View Subject | View Object

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Evidence c450a5a060
JSON

N2a cells over-expressing tau (Wang et al., 2017) and microglia also release tau in an exosome-dependent manner

a(MESH:Microglia) increases p(HGNC:MAPT) View Subject | View Object

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MeSH
Blood
MeSH
Cerebrospinal Fluid

Evidence 83307b103e
JSON

Tau is well-recognized for its role in assembling/stabilizing microtubules although tau single knockout mice do not show major phenotypic changes in neuronal microtubule stability because of a putative functional redundancy

act(a(MESH:Microtubules)) association p(HGNC:MAPT) View Subject | View Object

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p(HGNC:MAPT) association act(a(MESH:Microtubules)) View Subject | View Object

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Evidence 6faeadb8e5
JSON

In addition, stimulating neuronal activity in either cultured neurons or in vivo also enhances tau release

act(a(MESH:Neurons)) increases p(HGNC:MAPT) View Subject | View Object

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Evidence 1437a7b6ea
JSON

this observation suggests that the activity-dependent release of tau participates in a positive feedback loop on neuronal activity.

act(a(MESH:Neurons)) increases p(HGNC:MAPT) View Subject | View Object

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p(HGNC:MAPT) increases act(a(MESH:Neurons)) View Subject | View Object

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Evidence eb5ce1f7f1
JSON

CSF tau in APP transgenic mice is increased in an age- dependent manner without a global neuronal loss

a(MESH:Neurons) causesNoChange p(HGNC:MAPT) View Subject | View Object

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MeSH
Cerebrospinal Fluid

Evidence 1a2201cdd1
JSON

the application of extracellular tau increases the electrical activity of iPSC-derived or primary cortical neurons

p(HGNC:MAPT, loc(GO:"extracellular region")) increases act(a(MESH:Neurons)) View Subject | View Object

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Evidence dcdbfa0de5
JSON

Moreover, extracellular tau may elicit cellular toxicity under certain conditions.

p(HGNC:MAPT, loc(GO:"extracellular region")) decreases a(MESH:Neurons) View Subject | View Object

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Evidence c26b517044
JSON

Furthermore, extracellular oligomeric tau impairs memory and long-term potentiation (LTP) in mice

p(HGNC:MAPT, loc(GO:"extracellular region")) decreases path(MESH:Memory) View Subject | View Object

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p(HGNC:MAPT, loc(GO:"extracellular region")) decreases bp(MESH:"Long-Term Potentiation") View Subject | View Object

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Evidence 39d780bcb9
JSON

Anti-tau antibodies facilitate microglial uptake of tau aggregates

p(HGNC:MAPT) decreases p(HBP:"Tau aggregates") View Subject | View Object

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MeSH
Blood
MeSH
Cerebrospinal Fluid

Evidence 688081356e
JSON

Elevated CSF tau is a diagnostic biomarker in AD patients

p(HGNC:MAPT) biomarkerFor path(MESH:"Alzheimer Disease") View Subject | View Object

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MeSH
Cerebrospinal Fluid

Evidence a1e52743b9
JSON

However, other studies show that the majority of extracellular tau is membrane-free (Chai et al., 2012; Karch et al., 2012) and not associated with extracellular vesicles such as exosomes or ectosomes (i.e., plasma-membrane originating vesicles act(MESH:Exosomes) cnc p(HGNC:MAPT) SET Evidence =

complex(p(HGNC:HSPA8), p(INTERPRO:"Chaperone DnaJ")) decreases p(HGNC:MAPT) View Subject | View Object

Appears in Networks:
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MeSH
Blood
MeSH
Cerebrospinal Fluid

p(HGNC:SNAP23) increases p(HGNC:MAPT) View Subject | View Object

Appears in Networks:
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MeSH
Blood
MeSH
Cerebrospinal Fluid

p(MESH:"SNARE Proteins") increases p(HGNC:MAPT) View Subject | View Object

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MeSH
Blood
MeSH
Cerebrospinal Fluid

Evidence b1f53de3c6
JSON

The addition of tau into the cell culture media binds to muscarinic acetylcholine receptors and increases intracellular calcium, eventually leading to cell death

complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) increases a(MESH:Calcium) View Subject | View Object

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complex(p(HGNC:MAPT), p(MESH:"Receptors, Muscarinic")) decreases a(MESH:Neurons) View Subject | View Object

Appears in Networks:

Evidence 88a9b7fc4d
JSON

Subsequent studies have shown that injecting tau fibrils into the brain also induces trans- neuronal propagation in vivo

p(HBP:"Tau fibrils") increases tloc(p(HGNC:MAPT)) View Subject | View Object

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Evidence d21c641367
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Furthermore, caspase-3 cleavage at D421 increases tau release

act(p(HGNC:CASP3)) increases p(HGNC:MAPT) View Subject | View Object

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Evidence 799284953a
JSON

Rab GTPase regulates various steps of intracellular vesicle trafficking and membrane fusion

p(MESH:"rab GTP-Binding Proteins") regulates act(a(MESH:"Transport Vesicles")) View Subject | View Object

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MeSH
Blood
MeSH
Cerebrospinal Fluid

p(MESH:"rab GTP-Binding Proteins") regulates bp(MESH:"Membrane Fusion") View Subject | View Object

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Annotations
MeSH
Blood
MeSH
Cerebrospinal Fluid

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