1. Catalog
  2. Nodes
  3. a(CHEBI:clozapine)

a(CHEBI:clozapine)

Equivalencies: 0 | Classes: 0 | Children: 0 | Explore

Entity

Name
clozapine
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 2

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

mTOR-Related Brain Dysfunctions in Neuropsychiatric Disorders v1.0.0

In-Edges 1

p(HGNC:CHRNA7) association a(CHEBI:clozapine) View Subject | View Object

However, the atypical antipsychotic drug clozapine normalizes auditory gating in DBA/2 mice — an effect which involves an alpha7 nAChR mechanism181. PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

Out-Edges 9

a(CHEBI:clozapine) increases bp(MESH:"Sensory Gating") View Subject | View Object

However, the atypical antipsychotic drug clozapine normalizes auditory gating in DBA/2 mice — an effect which involves an alpha7 nAChR mechanism181. PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

a(CHEBI:clozapine) association p(HGNC:CHRNA7) View Subject | View Object

However, the atypical antipsychotic drug clozapine normalizes auditory gating in DBA/2 mice — an effect which involves an alpha7 nAChR mechanism181. PubMed:19721446

Appears in Networks:
Annotations
Text Location
Review

a(CHEBI:clozapine) increases bp(GO:autophagy) View Subject | View Object

Recently, in vitro studies on the effects of second-generation, atypical antipsychotics demonstrated that sertindole and clozapine are potent autophagy inducers in both neuronal and non-neuronal cell lines PubMed:30061532

Appears in Networks:

a(CHEBI:clozapine) increases bp(GO:autophagy) View Subject | View Object

Similar to pimozide, clozapine activates the autophagy process via the AMPK–ULK1–Beclin1 pathway, as evidenced by increased levels of autophagy markers (i.e., LC3-II and Atg5–Atg12 conjugate); increased phosphorylation of AMPK and its downstream substrates, namely ULK1 and beclin1; and an increased number of autophagosomes in the frontal cortex in clozapine-treated rats PubMed:30061532

Appears in Networks:

a(CHEBI:clozapine) increases p(HGNC:PRKAA1, pmod(Ph)) View Subject | View Object

Similar to pimozide, clozapine activates the autophagy process via the AMPK–ULK1–Beclin1 pathway, as evidenced by increased levels of autophagy markers (i.e., LC3-II and Atg5–Atg12 conjugate); increased phosphorylation of AMPK and its downstream substrates, namely ULK1 and beclin1; and an increased number of autophagosomes in the frontal cortex in clozapine-treated rats PubMed:30061532

Appears in Networks:

a(CHEBI:clozapine) increases p(HGNC:ULK1, pmod(Ph)) View Subject | View Object

Similar to pimozide, clozapine activates the autophagy process via the AMPK–ULK1–Beclin1 pathway, as evidenced by increased levels of autophagy markers (i.e., LC3-II and Atg5–Atg12 conjugate); increased phosphorylation of AMPK and its downstream substrates, namely ULK1 and beclin1; and an increased number of autophagosomes in the frontal cortex in clozapine-treated rats PubMed:30061532

Appears in Networks:

a(CHEBI:clozapine) increases p(HGNC:BECN1, pmod(Ph)) View Subject | View Object

Similar to pimozide, clozapine activates the autophagy process via the AMPK–ULK1–Beclin1 pathway, as evidenced by increased levels of autophagy markers (i.e., LC3-II and Atg5–Atg12 conjugate); increased phosphorylation of AMPK and its downstream substrates, namely ULK1 and beclin1; and an increased number of autophagosomes in the frontal cortex in clozapine-treated rats PubMed:30061532

Appears in Networks:

a(CHEBI:clozapine) increases a(GO:autophagosome) View Subject | View Object

Similar to pimozide, clozapine activates the autophagy process via the AMPK–ULK1–Beclin1 pathway, as evidenced by increased levels of autophagy markers (i.e., LC3-II and Atg5–Atg12 conjugate); increased phosphorylation of AMPK and its downstream substrates, namely ULK1 and beclin1; and an increased number of autophagosomes in the frontal cortex in clozapine-treated rats PubMed:30061532

Appears in Networks:
Annotations
MeSH
Frontal Lobe

a(CHEBI:clozapine) decreases a(CHEBI:"amyloid-beta") View Subject | View Object

Chronic clozapine treatment (20 mg/kg/day) reduces Abeta deposition PubMed:30061532

Appears in Networks:
Annotations
MeSH
Frontal Lobe

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.