a(CHEBI:clozapine) increases bp(GO:autophagy)

View Subject View Object

PubMed:30061532

Similar to pimozide, clozapine activates the autophagy process via the AMPK–ULK1–Beclin1 pathway, as evidenced by increased levels of autophagy markers (i.e., LC3-II and Atg5–Atg12 conjugate); increased phosphorylation of AMPK and its downstream substrates, namely ULK1 and beclin1; and an increased number of autophagosomes in the frontal cortex in clozapine-treated rats

Related Edges 4

• a(CHEBI:clozapine) increases p(HGNC:PRKAA1, pmod(Ph))
• a(CHEBI:clozapine) increases p(HGNC:ULK1, pmod(Ph))
• a(CHEBI:clozapine) increases p(HGNC:BECN1, pmod(Ph))
• a(CHEBI:clozapine) increases a(GO:autophagosome)

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.

---