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bp(MESH:"Sensory Gating")

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Entity

Name
Sensory Gating
Namespace
mesh
Namespace Version
20181007
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/8ccfed235e418e4c8aa576f9a5ef0f838e794c7f/external/mesh-names.belns

Appears in Networks 1

Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system v1.0.0

This document contains the curation of the review article Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system by Taly et al. 2009

In-Edges 8

a(CHEBI:clozapine) increases bp(MESH:"Sensory Gating") View Subject | View Object

However, the atypical antipsychotic drug clozapine normalizes auditory gating in DBA/2 mice — an effect which involves an alpha7 nAChR mechanism181. PubMed:19721446

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a(CHEBI:nicotine) increases bp(MESH:"Sensory Gating") View Subject | View Object

Patients with schizophrenia174 and DBA/2 mouse models180,181 respond to nicotine administration with improved sensory gating, presumably through alpha7 nAChR activation182,183. PubMed:19721446

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MeSH
Schizophrenia
Text Location
Review

a(CHEBI:tropisetron) decreases bp(MESH:"Sensory Gating") View Subject | View Object

Similarly, topisetron, a 5HT3 antagonist marketed outside the united States as an anti-nausea drug, also has efficacy as an alpha7 nAChR agonist and increases the inhibition of P50 auditory gating in schizophrenia185. PubMed:19721446

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Schizophrenia
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Review

a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") View Subject | View Object

GTS-21, one of a series of compounds derived from anabaseine, an alkaloid found in marine worms, is a partial agonist of alpha7 nAChRs that improves memory-related behaviours in various paradigms and normalizes auditory gating186. it is the leading clinical candidate in the field of alpha7 nAChRs. PubMed:19721446

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a(MESH:"3-(2,4-dimethoxybenzylidene)anabaseine") increases bp(MESH:"Sensory Gating") View Subject | View Object

initially evaluated in normal subjects, GTS-21 was found to significantly improve attention and memory. in a second Phase i trial187, GTS-21 normalized P50 auditory gating in patients with schizophrenia. PubMed:19721446

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p(HGNC:CHRNA7) association bp(MESH:"Sensory Gating") View Subject | View Object

in addition, a decrease in alpha7 nAChR density in the hippocampus of patients with schizophrenia has been reported177. Similarly, a low density of alpha7 nAChRs in inbred strains of mice is associated with poor gating178. Recently, the expression of a novel variant of alpha7 nAChR, CHRNA7-2 (cholinergic receptor, nicotinic, alpha7, variant 2), was found to be reduced below control levels in the prefrontal cortex of patients with schizophrenia179. PubMed:19721446

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p(HGNCGENEFAMILY:"Cholinergic receptors nicotinic subunits") regulates bp(MESH:"Sensory Gating") View Subject | View Object

nAChRs are known to control sensory gating, and studies investigating the role of nAChRs in schizophrenia have focused primarily on alpha7 nAChRs. Sensory-gating deficits in patients with schizophrenia174 have been linked to chromosome 15q14, proximal to the alpha7 locus175,176. PubMed:19721446

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path(MESH:Schizophrenia) association bp(MESH:"Sensory Gating") View Subject | View Object

nAChRs are known to control sensory gating, and studies investigating the role of nAChRs in schizophrenia have focused primarily on alpha7 nAChRs. Sensory-gating deficits in patients with schizophrenia174 have been linked to chromosome 15q14, proximal to the alpha7 locus175,176. PubMed:19721446

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Out-Edges 2

bp(MESH:"Sensory Gating") association path(MESH:Schizophrenia) View Subject | View Object

nAChRs are known to control sensory gating, and studies investigating the role of nAChRs in schizophrenia have focused primarily on alpha7 nAChRs. Sensory-gating deficits in patients with schizophrenia174 have been linked to chromosome 15q14, proximal to the alpha7 locus175,176. PubMed:19721446

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Review

bp(MESH:"Sensory Gating") association p(HGNC:CHRNA7) View Subject | View Object

in addition, a decrease in alpha7 nAChR density in the hippocampus of patients with schizophrenia has been reported177. Similarly, a low density of alpha7 nAChRs in inbred strains of mice is associated with poor gating178. Recently, the expression of a novel variant of alpha7 nAChR, CHRNA7-2 (cholinergic receptor, nicotinic, alpha7, variant 2), was found to be reduced below control levels in the prefrontal cortex of patients with schizophrenia179. PubMed:19721446

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If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.