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a(CHEBI:radical)

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Entity

Name
radical
Namespace
chebi
Namespace Version
20180906
Namespace URL
https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/chebi-names.belns

Appears in Networks 1

Molecular chaperones and proteostasis regulation during redox imbalance v1.0.0

In-Edges 9

a(MESH:"Air Pollution") increases a(CHEBI:radical) View Subject | View Object

Notably, free radicals may also arise from exogenous sources including various types of radiations (e.g. UV light, X-rays or gamma rays), atmospheric pollutants and metal-catalyzed reac- tions [1–3]. PubMed:24563850

Appears in Networks:

act(a(MESH:Peroxisomes)) increases a(CHEBI:radical) View Subject | View Object

Excessive amounts of free radicals and radical-derived reactive species may also arise from the activity of NAD(P)H oxidases (NOx) and/or xanthine oxidase, as well as from nitric oxide synthase (NOS), P450 metabolism and peroxisomes. PubMed:24563850

Appears in Networks:

bp(GO:"detection of redox state") association a(CHEBI:radical) View Subject | View Object

Free radicals were originally believed to be harmful, but it has been realized that in physiological concentrations they serve as redox messengers, which are essential in the regulation of intra- cellular signalling and significant cellular processes including meta- bolism, antioxidant defenses and responses to pathogens [1,4]. PubMed:24563850

Appears in Networks:

bp(GO:"response to radiation") increases a(CHEBI:radical) View Subject | View Object

Notably, free radicals may also arise from exogenous sources including various types of radiations (e.g. UV light, X-rays or gamma rays), atmospheric pollutants and metal-catalyzed reac- tions [1–3]. PubMed:24563850

Appears in Networks:

bp(MESH:"Host-Pathogen Interactions") association a(CHEBI:radical) View Subject | View Object

Free radicals were originally believed to be harmful, but it has been realized that in physiological concentrations they serve as redox messengers, which are essential in the regulation of intra- cellular signalling and significant cellular processes including meta- bolism, antioxidant defenses and responses to pathogens [1,4]. PubMed:24563850

Appears in Networks:

act(p(FPLX:"NADPH_oxidase")) increases a(CHEBI:radical) View Subject | View Object

Excessive amounts of free radicals and radical-derived reactive species may also arise from the activity of NAD(P)H oxidases (NOx) and/or xanthine oxidase, as well as from nitric oxide synthase (NOS), P450 metabolism and peroxisomes. PubMed:24563850

Appears in Networks:

act(p(FPLX:NOS)) increases a(CHEBI:radical) View Subject | View Object

Excessive amounts of free radicals and radical-derived reactive species may also arise from the activity of NAD(P)H oxidases (NOx) and/or xanthine oxidase, as well as from nitric oxide synthase (NOS), P450 metabolism and peroxisomes. PubMed:24563850

Appears in Networks:

act(p(HGNC:XDH)) increases a(CHEBI:radical) View Subject | View Object

Excessive amounts of free radicals and radical-derived reactive species may also arise from the activity of NAD(P)H oxidases (NOx) and/or xanthine oxidase, as well as from nitric oxide synthase (NOS), P450 metabolism and peroxisomes. PubMed:24563850

Appears in Networks:

act(p(HGNCGENEFAMILY:"Cytochrome P450 family 1")) increases a(CHEBI:radical) View Subject | View Object

Excessive amounts of free radicals and radical-derived reactive species may also arise from the activity of NAD(P)H oxidases (NOx) and/or xanthine oxidase, as well as from nitric oxide synthase (NOS), P450 metabolism and peroxisomes. PubMed:24563850

Appears in Networks:

Out-Edges 9

a(CHEBI:radical) increases bp(HBP:misfolding) View Subject | View Object

Free radicals-derived protein modification can result in either gain- or loss-of-function due to the protein misfolding or unfolding. PubMed:24563850

Appears in Networks:

a(CHEBI:radical) association bp(GO:"detection of redox state") View Subject | View Object

Free radicals were originally believed to be harmful, but it has been realized that in physiological concentrations they serve as redox messengers, which are essential in the regulation of intra- cellular signalling and significant cellular processes including meta- bolism, antioxidant defenses and responses to pathogens [1,4]. PubMed:24563850

Appears in Networks:

a(CHEBI:radical) regulates bp(GO:"intracellular receptor signaling pathway") View Subject | View Object

Free radicals were originally believed to be harmful, but it has been realized that in physiological concentrations they serve as redox messengers, which are essential in the regulation of intra- cellular signalling and significant cellular processes including meta- bolism, antioxidant defenses and responses to pathogens [1,4]. PubMed:24563850

Appears in Networks:

a(CHEBI:radical) regulates bp(MESH:Metabolism) View Subject | View Object

Free radicals were originally believed to be harmful, but it has been realized that in physiological concentrations they serve as redox messengers, which are essential in the regulation of intra- cellular signalling and significant cellular processes including meta- bolism, antioxidant defenses and responses to pathogens [1,4]. PubMed:24563850

Appears in Networks:

a(CHEBI:radical) decreases a(MESH:Antioxidants) View Subject | View Object

Free radicals were originally believed to be harmful, but it has been realized that in physiological concentrations they serve as redox messengers, which are essential in the regulation of intra- cellular signalling and significant cellular processes including meta- bolism, antioxidant defenses and responses to pathogens [1,4]. PubMed:24563850

Appears in Networks:

a(CHEBI:radical) association bp(MESH:"Host-Pathogen Interactions") View Subject | View Object

Free radicals were originally believed to be harmful, but it has been realized that in physiological concentrations they serve as redox messengers, which are essential in the regulation of intra- cellular signalling and significant cellular processes including meta- bolism, antioxidant defenses and responses to pathogens [1,4]. PubMed:24563850

Appears in Networks:

a(CHEBI:radical) increases bp(HBP:"non-enzymatic protein modification") View Subject | View Object

Free radicals-derived protein modification can result in either gain- or loss-of-function due to the protein misfolding or unfolding. PubMed:24563850

Appears in Networks:

a(CHEBI:radical) increases bp(GO:"protein oxidation") View Subject | View Object

Proteome oxidation and instability has been associated with ageing and the progression of several age-related diseases, including cardiovascular disorders, neu- rodegeneration, and cancer [7,95,96]. PubMed:24563850

Appears in Networks:

a(CHEBI:radical) increases bp(MESH:"Protein Carbonylation") View Subject | View Object

A frequent oxidative modification of proteins is irreversible carbonylation which can occur by either direct oxidation where oxidants act and leave a functional carbonyl group on amino acid side chains or in the protein backbone, or, indirectly, by protein conjugation with oxidation pro- ducts of polyunsaturated fatty acids and carbohydrates [98]. PubMed:24563850

Appears in Networks:

About

BEL Commons is developed and maintained in an academic capacity by Charles Tapley Hoyt and Daniel Domingo-Fernández at the Fraunhofer SCAI Department of Bioinformatics with support from the IMI project, AETIONOMY. It is built on top of PyBEL, an open source project. Please feel free to contact us here to give us feedback or report any issues. Also, see our Publishing Notes and Data Protection information.

If you find BEL Commons useful in your work, please consider citing: Hoyt, C. T., Domingo-Fernández, D., & Hofmann-Apitius, M. (2018). BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language. Database, 2018(3), 1–11.