bp(GO:"intracellular receptor signaling pathway")

Entity

Name

intracellular receptor signaling pathway

Namespace

go

Namespace Version

20180921

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/b46b65c3da259b6e86026514dfececab7c22a11b/external/go-names.belns

Curiously, although most studies are in agreement that nAChRs need to be activated to mediate their protective effects, mouse cortical neurons are protected by the alpha7 antagonist methyllycaconitine (Martin et al., 2004), raising the possibility that neuroprotection by alpha7 agonists may be through desensitization rather than activation of this rapidly desensitizing receptor. This would be consistent with the alpha7- dependent activation of intracellular signaling pathways by Abeta (Bell et al., 2004), but the opposite effects on cell survival exerted by Abeta and nicotine means that other mechanisms must be sought, such as ligand-specific coupling to downstream signaling pathways. PubMed:19293145

The cytoplasmic domain of the alpha􏰀4-nAChR subunit also binds a variety of scaffold proteins that interact with cytoskeletal proteins and with G protein systems that are involved in intracellular signaling pathways PubMed:23038257

it has recently been shown that the intra- cellular loop of the α7 subunit contains a G protein binding cluster that promotes intracellular signalling PubMed:28901280

Free radicals were originally believed to be harmful, but it has been realized that in physiological concentrations they serve as redox messengers, which are essential in the regulation of intra- cellular signalling and significant cellular processes including meta- bolism, antioxidant defenses and responses to pathogens [1,4]. PubMed:24563850

The cytoplasmic domain of the alpha􏰀4-nAChR subunit also binds a variety of scaffold proteins that interact with cytoskeletal proteins and with G protein systems that are involved in intracellular signaling pathways PubMed:23038257