bp(HBP:"non-enzymatic protein modification")

Entity

Name

non-enzymatic protein modification

Namespace

HBP

Namespace Version

20190309

Namespace URL

https://raw.githubusercontent.com/pharmacome/terminology/0c9853baf883545b922ff1b138a9f297a70b7951/export/hbp-names.belns

Free radicals-derived protein modification can result in either gain- or loss-of-function due to the protein misfolding or unfolding. PubMed:24563850

Proteome is modified post-translationally by either numerous highly regulated enzymatic protein modifications (EPMs) (e.g. phosphorylation, acetylation, ubiquitination, methylation, etc.) or by non-enzymatic protein modifications (NEPMs), which are mostly stochastic and increase with ageing or in age-related diseases (Fig. 1). PubMed:24563850

Proteome is modified post-translationally by either numerous highly regulated enzymatic protein modifications (EPMs) (e.g. phosphorylation, acetylation, ubiquitination, methylation, etc.) or by non-enzymatic protein modifications (NEPMs), which are mostly stochastic and increase with ageing or in age-related diseases (Fig. 1). PubMed:24563850

EPMs alter the targeted proteins, which however remain fully functional, while NEPMs may induce protein unfolding or misfolding resulting in increased proteome instability. PubMed:24563850